Pomegranate for Prevention and Treatment of Cancer: An Update.
Pomegranate for Prevention and Treatment of Cancer: An Update.
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DOI：
10.3390/molecules22010177
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发表时间：
2017-01-24
期刊：
影响因子：
--
通讯作者：
Afaq F
中科院分区：
文献类型：
--
作者：
Sharma P;McClees SF;Afaq F
癌症是美国第二大死因，那些在癌症中幸存下来的人可能会经历持久的困难，包括治疗副作用，以及身体、认知和心理社会斗争。来自饮食水果和蔬菜的天然制剂在预防和治疗癌症方面受到了相当大的关注。与昂贵的化疗药物相比，这些天然药物安全且成本效益高，因为昂贵的化疗药物可能会产生显著的副作用。石榴(Punica Gratum L.)在古代文化中，水果被用于预防和治疗多种疾病和疾病已有数百年的历史。石榴具有很强的抗氧化活性，富含花青素、鞣花单宁和可水解性单宁。研究表明，石榴果实及其果汁、提取物和油通过调节多种信号通路而发挥抗炎、抗增殖和抗肿瘤的作用，这表明它是一种很有前途的化学预防/化疗药物。本文综述了石榴在预防和治疗皮肤癌、乳腺癌、前列腺癌、肺癌和结肠癌方面的临床前和临床研究。
Cancer is the second leading cause of death in the United States, and those who survive cancer may experience lasting difficulties, including treatment side effects, as well as physical, cognitive, and psychosocial struggles. Naturally-occurring agents from dietary fruits and vegetables have received considerable attention for the prevention and treatment of cancers. These natural agents are safe and cost efficient in contrast to expensive chemotherapeutic agents, which may induce significant side effects. The pomegranate (Punica granatum L.) fruit has been used for the prevention and treatment of a multitude of diseases and ailments for centuries in ancient cultures. Pomegranate exhibits strong antioxidant activity and is a rich source of anthocyanins, ellagitannins, and hydrolysable tannins. Studies have shown that the pomegranate fruit as well as its juice, extract, and oil exert anti-inflammatory, anti-proliferative, and anti-tumorigenic properties by modulating multiple signaling pathways, which suggest its use as a promising chemopreventive/chemotherapeutic agent. This review summarizes preclinical and clinical studies highlighting the role of pomegranate in prevention and treatment of skin, breast, prostate, lung, and colon cancers.
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影响因子：
6.4
作者：
Afaq, F;Saleem, M;Mukhtar, H
通讯作者：
Mukhtar, H
影响因子：
4.3
作者：
Boateng, J.;Verghese, M.;Chawan, C. B.
通讯作者：
Chawan, C. B.
DOI：
10.3390/molecules19068644
发表时间：
2014-06-24
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Costantini S;Rusolo F;De Vito V;Moccia S;Picariello G;Capone F;Guerriero E;Castello G;Volpe MG
通讯作者：
Volpe MG
影响因子：
3.6
作者：
Afaq F;Zaid MA;Khan N;Dreher M;Mukhtar H
通讯作者：
Mukhtar H
DOI：
10.1158/1940-6207.capr-09-0161
发表时间：
2010-06
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Bobe G;Albert PS;Sansbury LB;Lanza E;Schatzkin A;Colburn NH;Cross AJ
通讯作者：
Cross AJ