Repetitive transcranial magnetic stimulation decreased effortful frontal activity for shifting in patients with major depressive disorder
Repetitive transcranial magnetic stimulation decreased effortful frontal activity for shifting in patients with major depressive disorder
复制标题
重复经颅磁刺激减少了重度抑郁症患者移动时的费力额叶活动
DOI：
10.1097/wnr.0000000000001806
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发表时间：
2022
期刊：
影响因子：
1.7
通讯作者：
Kito Shinsuke
中科院分区：
文献类型：
--
作者：
Shirakawa Yuka;Yamazaki Ryuichi;Kita Yosuke;Kitamura Yuzuki;Okumura Yasuko;Inoue Yuki;Matsuda Yuki;Kodaka Fumitoshi;Shigeta Masahiro;Kito Shinsuke
重度抑郁障碍（MDD）患者表现出包括灵活思维困难在内的几种临床症状。灵活思维主要依赖于一种被称为转移的认知能力；然而，MDD患者转变的机制尚不清楚。因此，我们进行了一项初步的干预研究，以澄清抑郁与转移能力之间的关系。我们使用功能性近红外光谱（fNIRS）检测了21例接受高频重复经颅磁刺激（rTMS）治疗的重度抑郁症患者在转移任务期间额叶区域的血流动力学反应。在转移任务上的行为表现在治疗前后没有变化，而对rTMS治疗反应良好的患者在治疗后的血流动力学反应显著降低。另一方面，不良反应者在治疗前后的血流动力学反应没有显着变化。这些结果表明，反应良好的人通过rTMS治疗成功地纠正了错误，并且不需要在额叶区域进行费力的活动来转移，这使得他们的大脑活动更有效。
Patients with major depressive disorder (MDD) exhibit several clinical symptoms including difficulties in flexible thinking. Flexible thinking mainly relies on a cognitive ability called shifting; however, the mechanisms underlying shifting in patients with MDD have not yet been clarified. Therefore, we conducted a preliminary intervention study to clarify the association between depression and shifting ability. We examined the hemodynamic responses in the frontal regions during the shifting task using functional near-infrared spectroscopy (fNIRS) in 21 patients with MDD who were treated using high-frequency repetitive transcranial magnetic stimulation (rTMS). Behavioral performance on the shifting task did not change between pre-and posttreatments, whereas patients who responded well to rTMS treatment showed a significant decrease in hemodynamic responses posttreatment. On the other hand, the poor responders did not show significant changes in the hemodynamic responses between pre-and posttreatments. These results suggest that the good responders were successfully remedied with rTMS treatment and did not need effortful activity in frontal regions for shifting, which made their brain activity more efficient.
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影响因子：
5.7
作者：
Strangman, G;Culver, JP;Boas, DA
通讯作者：
Boas, DA
影响因子：
22.4
作者：
Snyder, Hannah R.
通讯作者：
Snyder, Hannah R.
DOI：
10.1037//0012-1649.33.3.480
发表时间：
1997
期刊：
Developmental psychology.
影响因子：
--
作者：
Fagot,BI;Gauvain,M
通讯作者：
Gauvain,M
影响因子：
25
作者：
Konishi, S;Nakajima, K;Miyashita, Y
通讯作者：
Miyashita, Y