Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks.
Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks.
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DOI：
10.1016/j.devcel.2012.07.008
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发表时间：
2012-09-11
影响因子：
11.8
通讯作者：
McMahon, Andrew P.
中科院分区：
文献类型：
--
作者：
Park, Joo-Seop;Ma, Wenxiu;O'Brien, Lori L.;Chung, Eunah;Guo, Jin-Jin;Cheng, Jr-Gang;Valerius, M. Todd;McMahon, Jill A.;Wong, Wing Hung;McMahon, Andrew P.
使用染色质免疫沉淀和转录分析确定了六个依赖性的自我更新和典型的WNT信号定向的效果 - 每个基因两侧的调节模块由六个和β-catenin共同结合，并依赖于型LEF/TCF结合位点进行活性，并在体内分析。维持β-catenin进入该复合物会促进肾脏形成。 。
A balance between Six2-dependent self-renewal and canonical Wnt signaling-directed commitment regulates mammalian nephrogenesis. Intersectional studies using chromatin immunoprecipitation and transcriptional profiling identified direct target genes shared by each pathway within nephron progenitors. Wnt4 and Fgf8 are essential for progenitor commitment; cis-regulatory modules flanking each gene are co-bound by Six2 and β-catenin, and dependent on conserved Lef/Tcf binding sites for activity. In vitro and in vivo analyses suggest that Six2 and Lef/Tcf factors form a regulatory complex that promotes progenitor maintenance while entry of β-catenin into this complex promotes nephrogenesis. Alternative transcriptional responses associated with Six2 and β-catenin co-binding events occur through non-Lef/Tcf DNA binding mechanisms highlighting the regulatory complexity downstream of Wnt signaling in the developing mammalian kidney.
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影响因子：
11.8
作者：
Carroll, TJ;Park, JS;McMahon, AP
通讯作者：
McMahon, AP
DOI：
10.1073/pnas.011404098
发表时间：
2001-01-02
影响因子：
11.1
作者：
Li, C;Wong, WH
通讯作者：
Wong, WH
DOI：
10.1126/science.1162327
发表时间：
2009-06-26
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Badis G;Berger MF;Philippakis AA;Talukder S;Gehrke AR;Jaeger SA;Chan ET;Metzler G;Vedenko A;Chen X;Kuznetsov H;Wang CF;Coburn D;Newburger DE;Morris Q;Hughes TR;Bulyk ML
通讯作者：
Bulyk ML
影响因子：
46.9
作者：
Ji, Hongkai;Jiang, Hui;Ma, Wenxiu;Johnson, David S.;Myers, Richard M.;Wong, Wing H.
通讯作者：
Wong, Wing H.
影响因子：
2.7
作者：
Georgas, Kylie;Rumballe, Bree;Little, Melissa H.
通讯作者：
Little, Melissa H.