Slow waves, synaptic plasticity and information processing: insights from transcranial magnetic stimulation and high-density EEG experiments.
Slow waves, synaptic plasticity and information processing: insights from transcranial magnetic stimulation and high-density EEG experiments.
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DOI：
10.1111/j.1460-9568.2009.06720.x
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发表时间：
2009-05
期刊：
影响因子：
--
通讯作者：
Huber R
中科院分区：
文献类型：
--
作者：
Massimini M;Tononi G;Huber R
睡眠慢波是NREM睡眠的主要现象。它们是自我平衡调节的，被认为与学习和可塑性过程有关，同时，它们与皮质信息处理的显著变化有关。使用经颅磁刺激（TMS）和高密度（HD）EEG，我们可以测量慢波，诱导/测量大脑皮层的可塑性变化，我们可以直接评估皮质-皮质信息传输。在这篇手稿中，我们回顾了最近的实验结果，其中TMS/HD-EEG被用来证明（i）皮质可塑性变化和睡眠慢波之间的因果关系和（ii）慢波和丘脑皮层回路的能力下降之间的因果关系，以整合信息，并在NREM睡眠期间产生有意识的经验。这里提出的数据表明，一个统一的机制连接慢波，可塑性和皮层信息整合，此外，他们建议，TMS可以用作一种非药理手段，可控地诱导慢波在人类大脑皮层。
Sleep slow waves are the main phenomenon underlying NREM sleep. They are homeostatically regulated, they are thought to be linked to learning and plasticity processes and, at the same time, they are associated with marked changes in cortical information processing. Using transcranial magnetic stimulation (TMS) and high-density (hd) EEG we can measure slow waves, induce/measure plastic changes in the cerebral cortex and we can directly assess cortico-cortical information transmission. In this manuscript we review the results of recent experiments in which TMS/hd-EEG is used to demonstrate (i) a causal link between cortical plastic changes and sleep slow waves and (ii) a causal link between slow waves and the decreased ability of thalamocortical circuits to integrate information and to generate conscious experience during NREM sleep. The data presented here suggest a unifying mechanism linking slow waves, plasticity and cortical information integration; moreover, they suggest that TMS can be used as a non-pharmacological mean to controllably induce slow waves in the human cerebral cortex.
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影响因子：
5.3
作者：
Aeschbach, Daniel;Cutler, Alex J.;Ronda, Joseph M.
通讯作者：
Ronda, Joseph M.
影响因子：
5.5
作者：
BLISS, TVP;LOMO, T
通讯作者：
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影响因子：
--
作者：
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通讯作者：
Berger, H
DOI：
10.1073/pnas.0807010105
发表时间：
2008-10-14
影响因子：
11.1
作者：
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通讯作者：
Raichle, Marcus E.
影响因子：
5.3
作者：
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