Micro-CT of rodents: state-of-the-art and future perspectives.
Micro-CT of rodents: state-of-the-art and future perspectives.
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DOI：
10.1016/j.ejmp.2014.05.011
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发表时间：
2014-09
期刊：
影响因子：
--
通讯作者：
Badea CT
中科院分区：
文献类型：
--
作者：
Clark DP;Badea CT
微型计算机断层扫描（micro-CT）是一种重要的工具，用于表型分析和阐明疾病及其治疗。这项工作的重点是临床前显微CT成像，审查相关的原则，技术和应用。通常，微型CT提供高分辨率解剖信息，或者单独提供，或者与低分辨率功能成像模式（如正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT））结合使用。然而，最近，微型CT的高级应用通过将临床应用转化为模型系统（例如测量心脏功能指标）和通过开创新系统（例如用纳米颗粒造影剂测量肿瘤血管渗透性）来产生功能信息。显微CT成像的主要限制是相关的辐射剂量和相对较差的软组织对比度。我们回顾了几种基于迭代，统计和梯度稀疏正则化的图像重建策略，证明了高图像质量是可以实现的，低辐射剂量给予更强大的计算资源。我们还回顾了两种对比机制在激烈的发展。第一种是光谱对比度，用于定量材料鉴别，与被动或主动靶向纳米颗粒造影剂组合。第二种是相位对比，其测量生物组织中的折射，以相对于标准吸收成像提高对比度并潜在地降低辐射剂量。这些技术进步有望将micro-CT发展成为一种普通的，功能性的甚至分子成像方式。
Micron-scale computed tomography (micro-CT) is an essential tool for phenotyping and for elucidating diseases and their therapies. This work is focused on preclinical micro-CT imaging, reviewing relevant principles, technologies, and applications. Commonly, micro-CT provides high-resolution anatomic information, either on its own or in conjunction with lower-resolution functional imaging modalities such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT). More recently, however, advanced applications of micro-CT produce functional information by translating clinical applications to model systems (e.g. measuring cardiac functional metrics) and by pioneering new ones (e.g. measuring tumor vascular permeability with nanoparticle contrast agents). The primary limitations of micro-CT imaging are the associated radiation dose and relatively poor soft tissue contrast. We review several image reconstruction strategies based on iterative, statistical, and gradient sparsity regularization, demonstrating that high image quality is achievable with low radiation dose given ever more powerful computational resources. We also review two contrast mechanisms under intense development. The first is spectral contrast for quantitative material discrimination in combination with passive or actively targeted nanoparticle contrast agents. The second is phase contrast which measures refraction in biological tissues for improved contrast and potentially reduced radiation dose relative to standard absorption imaging. These technological advancements promise to develop micro-CT into a commonplace, functional and even molecular imaging modality.
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影响因子：
3.5
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通讯作者：
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