The Application of Prussian Blue Nanoparticles in Tumor Diagnosis and Treatment.
The Application of Prussian Blue Nanoparticles in Tumor Diagnosis and Treatment.
复制标题
普鲁士蓝纳米粒子在肿瘤诊治中的应用
DOI：
10.3390/s20236905
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发表时间：
2020-12-03
期刊：
影响因子：
--
通讯作者：
Han X
中科院分区：
文献类型：
--
作者：
Gao X;Wang Q;Cheng C;Lin S;Lin T;Liu C;Han X
普鲁士蓝纳米粒子（PBNPs）具有大孔容、尺寸可调、易于合成和表面修饰、热稳定性好、生物相容性好等优点，在免疫传感器、生物成像、药物释放和治疗等方面有着广泛的应用前景。本文首先概述了基于PBNPs的免疫传感器对肿瘤标志物的影响，PBNPs具有竞争型结构和竞争型结构。金属离子掺杂的PBNPs作为T1加权磁共振和光声成像剂，以改善图像质量和表面修饰的PBNPs作为药物载体，通过被动或主动靶向肿瘤部位，以减少副作用也进行了总结。此外，具有高光热效率和良好的过氧化氢酶样活性的PBNPs在肿瘤的光热治疗和O2自给光动力治疗中具有很好的应用前景。因此，PBNP为基础的多模式成像引导的组合肿瘤治疗（如化疗，光热，光动力疗法）的最后审查。本文就PBNPs的合理设计及其在肿瘤检测和治疗中的应用进行综述。
Prussian blue nanoparticles (PBNPs) have attracted increasing research interest in immunosensors, bioimaging, drug delivery, and application as therapeutic agents due to their large internal pore volume, tunable size, easy synthesis and surface modification, good thermal stability, and favorable biocompatibility. This review first outlines the effect of tumor markers using PBNPs-based immunosensors which have a sandwich-type architecture and competitive-type structure. Metal ion doped PBNPs which were used as T1-weight magnetic resonance and photoacoustic imaging agents to improve image quality and surface modified PBNPs which were used as drug carriers to decrease side effects via passive or active targeting to tumor sites are also summarized. Moreover, the PBNPs with high photothermal efficiency and excellent catalase-like activity were promising for photothermal therapy and O2 self-supplied photodynamic therapy of tumors. Hence, PBNPs-based multimodal imaging-guided combinational tumor therapies (such as chemo, photothermal, and photodynamic therapies) were finally reviewed. This review aims to inspire broad interest in the rational design and application of PBNPs for detecting and treating tumors in clinical research.
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