Calcium Signaling Regulates Autophagy and Apoptosis.
Calcium Signaling Regulates Autophagy and Apoptosis.
复制标题
DOI：
10.3390/cells10082125
复制
发表时间：
2021-08-18
期刊：
影响因子：
6
通讯作者：
Singh BB
中科院分区：
文献类型：
--
作者：
Sukumaran P;Nascimento Da Conceicao V;Sun Y;Ahamad N;Saraiva LR;Selvaraj S;Singh BB
钙（Ca 2+）作为第二信使发挥作用，其在调节基本生理功能如细胞生长/发育、细胞存活、神经元发育和/或细胞功能的维持中至关重要。各种蛋白质/泵/Ca 2+通道和各种细胞器中的Ca 2+储存之间的协调对于维持胞质Ca 2+水平至关重要，胞质Ca 2+水平提供细胞稳态所需的空间分辨率。Ca 2+稳态的一个重要调节方面是钙库操纵的Ca 2+进入（SOCE）机制，其通过消耗来自内部ER库的Ca 2+而被激活，并且由于影响可兴奋和不可兴奋细胞中的功能而受到广泛关注。Ca 2+已被证明可以调节相反的功能，如自噬，促进细胞存活;另一方面，Ca 2+还调节程序性细胞死亡过程，如凋亡。TRP/奥赖通道的功能意义已被详细研究;然而，关于它们如何调节相反功能以及调节可兴奋和不可兴奋细胞中的功能的信息是有限的。重要的是，SOCE的扰动与一系列病理性神经退行性疾病有关。自噬机制在神经退行性疾病（如阿尔茨海默氏病、帕金森氏病和亨廷顿氏病）发病机制中的关键作用可能会揭示这些疾病合理治疗干预的途径。因此，我们审查的作用SOCE调节的Ca 2+信号在调节这些不同的功能，在干细胞，免疫调节和神经调节。
Calcium (Ca2+) functions as a second messenger that is critical in regulating fundamental physiological functions such as cell growth/development, cell survival, neuronal development and/or the maintenance of cellular functions. The coordination among various proteins/pumps/Ca2+ channels and Ca2+ storage in various organelles is critical in maintaining cytosolic Ca2+ levels that provide the spatial resolution needed for cellular homeostasis. An important regulatory aspect of Ca2+ homeostasis is a store operated Ca2+ entry (SOCE) mechanism that is activated by the depletion of Ca2+ from internal ER stores and has gained much attention for influencing functions in both excitable and non-excitable cells. Ca2+ has been shown to regulate opposing functions such as autophagy, that promote cell survival; on the other hand, Ca2+ also regulates programmed cell death processes such as apoptosis. The functional significance of the TRP/Orai channels has been elaborately studied; however, information on how they can modulate opposing functions and modulate function in excitable and non-excitable cells is limited. Importantly, perturbations in SOCE have been implicated in a spectrum of pathological neurodegenerative conditions. The critical role of autophagy machinery in the pathogenesis of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s diseases, would presumably unveil avenues for plausible therapeutic interventions for these diseases. We thus review the role of SOCE-regulated Ca2+ signaling in modulating these diverse functions in stem cell, immune regulation and neuromodulation.
登录
查看更多内容
影响因子：
5.8
作者：
Chauhan A;Sun Y;Sukumaran P;Quenum Zangbede FO;Jondle CN;Sharma A;Evans DL;Chauhan P;Szlabick RE;Aaland MO;Birnbaumer L;Sharma J;Singh BB;Mishra BB
通讯作者：
Mishra BB
影响因子：
4.1
作者：
Ahamad N;Singh BB
通讯作者：
Singh BB
影响因子：
64.5
作者：
Cárdenas C;Miller RA;Smith I;Bui T;Molgó J;Müller M;Vais H;Cheung KH;Yang J;Parker I;Thompson CB;Birnbaum MJ;Hallows KR;Foskett JK
通讯作者：
Foskett JK
神经元中的自噬诱导和自噬体清除：与阿尔茨海默氏病自噬病理学的关系。
影响因子：
5.3
作者：
Boland, Barry;Kumar, Asok;Lee, Sooyeon;Platt, Frances M.;Wegiel, Jerzy;Yu, W. Haung;Nixon, Ralph A.
通讯作者：
Nixon, Ralph A.
影响因子：
14.8
作者：
Barmada, Sami J.;Serio, Andrea;Arjun, Arpana;Bilican, Bilada;Daub, Aaron;Ando, D. Michael;Tsvetkov, Andrey;Pleiss, Michael;Li, Xingli;Peisach, Daniel;Shaw, Christopher;Chandran, Siddharthan;Finkbeiner, Steven
通讯作者：
Finkbeiner, Steven