Liquid ventilation: an adjunct for respiratory management
Liquid ventilation: an adjunct for respiratory management
复制标题
液体通气:呼吸管理的辅助手段
DOI:
--
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发表时间:
2004
期刊:
影响因子:
--
通讯作者:
T. Shaffer
中科院分区:
文献类型:
--
作者:
M. Wolfson;T. Shaffer
Although significant advances in respiratory care have reduced mortality of patients with respiratory failure, morbidity persists, often resulting from iatrogenic mechanisms. Mechanical ventilation with gas has been shown to initiate as well as exacerbate underlying lung injury, resulting in progressive structural damage and release of inflammatory mediators within the lung. Alternative means to support pulmonary gas exchange while preserving lung structure and function are therefore required. Perfluorochemical (PFC) liquids are currently used clinically in a number of ways, such as intravascular PFC emulsions for volume expansion/oxygen carrying/angiography and intracavitary neat PFC liquid for image contrast enhancement or vitreous fluid replacement. As a novel approach to replace gas as the respiratory medium, liquid assisted ventilation (LAV) with PFC liquids has been investigated as an alternative respiratory modality for over 30 years. Currently, there are several theoretical and practical applications of LAV in the immature or mature lung at risk for acute respiratory distress and injury associated with mechanical ventilation.
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DOI:
10.1152/jappl.1997.83.5.1666
发表时间:
1997
期刊:
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子:
--
作者:
Younger,JG;Taqi,AS;Till,GO;Hirschl,RB
通讯作者:
Hirschl,RB
影响因子:
4.8
作者:
Milestone,BN;MillerJr,T;Wolfson,MR;Stern,RG;Shaffer,TH
通讯作者:
Shaffer,TH
影响因子:
8.8
作者:
Hirschl,RB;Merz,SI;Montoya,JP;Parent,A;Wolfson,MR;Shaffer,TH;Bartlett,RH
通讯作者:
Bartlett,RH
影响因子:
19.7
作者:
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通讯作者:
Shaffer,TH
DOI:
10.1152/jappl.1988.65.3.1436
发表时间:
1988
期刊:
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子:
--
作者:
Wolfson,MR;Tran,N;Bhutani,VK;Shaffer,TH
通讯作者:
Shaffer,TH