Liquid ventilation: an adjunct for respiratory management

Liquid ventilation: an adjunct for respiratory management
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液体通气:呼吸管理的辅助手段

DOI:
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发表时间:
2004
期刊:
Paediatric anaesthesia
影响因子:
--
通讯作者:
T. Shaffer
T. Shaffer
中科院分区:
--
文献类型:
--
作者:
M. Wolfson;T. Shaffer

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虽然呼吸护理的显著进步降低了呼吸衰竭患者的死亡率,但发病率仍然存在,通常是医源性机制造成的。已显示使用气体的机械通气会引发以及加重潜在的肺损伤,导致肺内进行性结构损伤和炎性介质的释放。因此,需要在保持肺结构和功能的同时支持肺气体交换的替代手段。全氟化合物(PFC)液体目前以多种方式在临床上使用,例如用于体积扩张/携氧/血管造影术的血管内PFC乳液和用于图像对比度增强或玻璃体流体置换的腔内纯PFC液体。作为一种替代气体作为呼吸介质的新方法,使用PFC液体的液体辅助通气(LAV)已被研究作为替代呼吸模式超过30年。 目前,有几个理论和实际应用LAV在未成熟或成熟的肺急性呼吸窘迫和损伤的风险与机械通气。
Although significant advances in respiratory care have reduced mortality of patients with respiratory failure, morbidity persists, often resulting from iatrogenic mechanisms. Mechanical ventilation with gas has been shown to initiate as well as exacerbate underlying lung injury, resulting in progressive structural damage and release of inflammatory mediators within the lung. Alternative means to support pulmonary gas exchange while preserving lung structure and function are therefore required. Perfluorochemical (PFC) liquids are currently used clinically in a number of ways, such as intravascular PFC emulsions for volume expansion/oxygen carrying/angiography and intracavitary neat PFC liquid for image contrast enhancement or vitreous fluid replacement. As a novel approach to replace gas as the respiratory medium, liquid assisted ventilation (LAV) with PFC liquids has been investigated as an alternative respiratory modality for over 30 years. Currently, there are several theoretical and practical applications of LAV in the immature or mature lung at risk for acute respiratory distress and injury associated with mechanical ventilation.
部分液体通气可在复苏过程中保护肺部免受休克。
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