Breath Methane Levels Are Increased Among Patients with Diverticulosis.
Breath Methane Levels Are Increased Among Patients with Diverticulosis.
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DOI：
10.1007/s10620-016-4174-6
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发表时间：
2016-09
影响因子：
3.1
通讯作者：
Mutlu EA
中科院分区：
文献类型：
--
作者：
Yazici C;Arslan DC;Abraham R;Cushing K;Keshavarzian A;Mutlu EA
憩室病及其并发症是美国乃至整个西方世界的重要医疗保健问题。虽然憩室病发生的机制已部分探索，但很少有研究调查人类结肠气体（如甲烷）与憩室病之间的关系。本研究旨在证明产甲烷古菌与憩室病的发展之间的潜在关系。2003年至2010年间在拉什大学医学中心（RUMC）连续接受氢呼气试验（HBT）的受试者通过数据库进行回顾性识别。检查了医疗记录，看是否有结肠镜检查报告。确定了264名受试者，他们有呼吸甲烷水平测量和结肠镜检查结果。通过图表回顾获得了额外的人口统计学和临床数据。憩室病患者的平均呼吸甲烷水平高于未患憩室病患者（7.89 ppm对4.94 ppm, p=0.04）。甲烷产生者（定义为基线空腹呼吸甲烷水平为5ppm）在憩室病患者中比无憩室病患者更常见（50.9% vs. 34%, p=0.0025）。当校正混杂因素后，呼吸甲烷水平和年龄是结肠镜检查憩室病的两个独立预测因子。产甲烷与憩室病有关。需要进一步的研究来证实我们的发现，并前瞻性地评估产甲烷和产甲烷古菌在憩室病中的可能病因学作用。
Diverticulosis and its complications are important healthcare problems in the United States and throughout the Western world. While mechanisms as to how diverticulosis occurs have partially been explored, few studies examined the relationship between colonic gases such as methane and diverticulosis in humans. This study aimed to demonstrate prospective relationship between methanogenic Archaea and development of diverticulosis. Subjects who consecutively underwent hydrogen breath test (HBT) at Rush University Medical Center (RUMC) between 2003 and 2010 were identified retrospectively through a database. Medical records were reviewed for presence of a colonoscopy report. Two hundred and sixty four subjects were identified who had both a breath methane level measurement and a colonoscopy result. Additional demographic and clinical data were obtained with chart review. Mean breath methane levels were higher in subjects with diverticulosis compared to those without diverticulosis (7.89 ppm vs. 4.94 ppm, p=0.04). Methane producers (defined as those with baseline fasting breath methane level >5 ppm) were more frequent among subjects with diverticulosis compared to those without diverticulosis (50.9% vs. 34%, p=0.0025). When adjusted for confounders, breath methane levels and age were the two independent predictors of diverticulosis on colonoscopy with logistic regression modeling. Methanogenesis is associated with presence of diverticulosis. Further studies are needed to confirm our findings and prospectively evaluate a possible etiological role of methanogenesis and methanogenic archaea in diverticulosis.
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