Retrosplenial Cortical Connectivity with Frontal Basal Ganglia Networks.
Retrosplenial Cortical Connectivity with Frontal Basal Ganglia Networks.
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DOI：
10.1162/jocn_a_01699
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发表时间：
2021-05-01
影响因子：
3.2
通讯作者：
Heilbronner SR
中科院分区：
文献类型：
--
作者：
Monko ME;Heilbronner SR
以前对压后皮质（RSC）的研究集中在其在导航和记忆中的作用，与其成熟的内侧颞叶连接一致，但最近的证据也表明该区域在奖励和决策中的作用。由于功能在很大程度上是由解剖连接决定的，为了更好地理解RSC的解剖结构，我们使用追踪方法来检查大鼠RSC和额纹状体网络（典型的奖励和决策电路）之间的解剖连接。我们发现，在额叶皮层区域，RSC双向连接最强烈的前扣带皮层，但也与中央内侧眶额皮质区。RSC项目的背内侧纹状体，其终端领域几乎涵盖了额纹状体投射区，提示通过基底神经节的功能会聚。这种重叠是由前扣带皮层、前边缘皮层和眶额皮层驱动的，所有这些都有助于目标导向的决策，这表明RSC参与了类似的过程。
Previous studies of the retrosplenial cortex (RSC) have focused on its role in navigation and memory, consistent with its well-established medial temporal connections, but recent evidence also suggests a role for this region in reward and decision-making. Because function is determined largely by anatomical connections, and to better understand the anatomy of RSC, we used tract-tracing methods to examine the anatomical connectivity between the rat RSC and frontostriatal networks (canonical reward and decision-making circuits). We find that, among frontal cortical regions, RSC bidirectionally connects most strongly with the anterior cingulate cortex, but also with an area of the central-medial orbitofrontal cortex. RSC projects to the dorsomedial striatum, and its terminal fields are virtually encompassed by the frontal-striatal projection zone, suggestive of functional convergence through the basal ganglia. This overlap is driven by anterior cingulate cortex, prelimbic cortex, and orbitofrontal cortex, all of which contribute to goal-directed decision-making, suggesting that the RSC is involved in similar processes.
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