Effects of the basic multicellular unit and lamellar thickness on osteonal fatigue life.
Effects of the basic multicellular unit and lamellar thickness on osteonal fatigue life.
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DOI：
10.1016/j.jbiomech.2017.06.006
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发表时间：
2017-07-26
影响因子：
2.4
通讯作者：
Fritton JC
中科院分区：
文献类型：
--
作者：
Pellegrino G;Roman M;Fritton JC
一个重塑周期决定了骨单位和相关骨板在基本多细胞单位中的大小。治疗和老化影响这些微观结构特征。我们先前证实了高剂量双膦酸盐治疗的皮质骨疲劳寿命降低，机制不明，骨单位尺寸减小。在此，检查了三个有限元模型：1）单个骨单位，作为均质单元，具有异质椎板和椎板间，2）对照，仅骨组织和3）骨单位，骨水泥线设置在间质组织内。在模拟正弦弯曲疲劳中加载模型。随着骨单位尺寸的减小，每个模型的板层数量和板层厚度逐渐调整。正如假设的那样，较大的1型模型中的椎板达到了更大的失效周期，并且向2型模型中添加骨单位（生成3型模型集）产生了更长的疲劳寿命。然而，随着骨单位尺寸的减小，与骨单位相比，骨单位层内压缩损伤成核的潜力增加。此外，骨单位与更少，更厚的椎板显示增加疲劳寿命。骨组织微结构在损伤起始位置起作用，尤其是当BMU尺寸较小时。我们和其他人以前的发现可以部分解释为进一步理解更小骨单位中损伤成核的可能性增加。
A remodeling cycle sets the size of the osteon and associated lamellae in the basic multicellular unit. Treatments and aging affect these micro-structural features. We previously demonstrated decreased fatigue life with an unexplained mechanism and decreased osteon size in cortical bone treated with high-dose bisphosphonate. Here, three finite element models were examined: 1) a single osteon, as a homogeneous unit and with heterogeneous lamellae and interlamellae, 2) a control, interstitial-only tissue and 3) the osteon with cement line, set within the interstitial tissue. Models were loaded in simulated, sinusoidal bending fatigue. As osteon size was decreased, lamellar number and lamellar thickness were incrementally adjusted for each model. As hypothesized, lamellae within the larger type-1 models attained greater cycles to failure and the addition of an osteon to type-2 models (generating a type-3 model set) yielded increased fatigue life. However, as the osteon size was decreased, the potential for compressive damage nucleation was increased within the lamellae of the osteons versus the interstitium. Also, osteons with fewer, thicker lamellae displayed increased fatigue life. Osteonal microstructure plays a role in damage initiation location, especially when BMU size is smaller. Previous findings by us and others could partially be explained by this further understanding of increased probability for damage nucleation in smaller osteons.
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影响因子：
2.4
作者：
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通讯作者：
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影响因子：
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