Differentiation of infiltrative cardiomyopathy from hypertrophic cardiomyopathy using high-sensitivity cardiac troponin T: a case-control study.
Differentiation of infiltrative cardiomyopathy from hypertrophic cardiomyopathy using high-sensitivity cardiac troponin T: a case-control study.
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DOI：
10.1186/s12872-015-0043-z
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发表时间：
2015-06-16
影响因子：
2.1
通讯作者：
Kitaoka H
中科院分区：
文献类型：
--
作者：
Kubo T;Baba Y;Hirota T;Tanioka K;Yamasaki N;Yamanaka S;Iiyama T;Kumagai N;Furuno T;Sugiura T;Kitaoka H
由于浸润性心肌病和肥厚型心肌病(HCM)具有相同的临床和血流动力学特征，表现为左室肥厚和舒张期功能异常，因此往往很难区分它们。我们研究了高敏感性心肌肌钙蛋白T(hs-cTnT)在鉴别浸润性心肌病和肥厚型心肌病中的潜在作用。研究组包括连续46例在高知医学院医院发现肌节蛋白基因突变的浸润型心肌病或肥厚型心肌病患者，其中11例浸润型心肌病患者(心脏淀粉样变性8例，Fabry病3例)和35例肥厚型心肌病患者。浸润性心肌病组血清hs-cTnT水平显著高于肥厚型心肌病组(0.083 ± 0.057 ng/ml对0.027 ± 0.034 ng/ml，p <； 0.001)，而脑利钠肽水平在两组间无显著差异。在两组年龄匹配的患者(年龄40岁的 和GT； )中，hs-cTnT水平、最大室壁厚度、后壁厚度、二尖瓣早期充盈峰值(E峰)、舒张期早期峰值血流速度(Ea)、组织多普勒组织成像(Ea)外侧角血流速度及E/Ea比值在两组间均有显著差异。在受试者工作特性分析区分两组的准确性方面，hs-cTnT曲线下面积最高(0.939)，E/EA(外侧)次之(0.914)。血清hs-cTnT是准确鉴别浸润性心肌病和肥厚型心肌病的有用诊断指标。
Because infiltrative cardiomyopathy and hypertrophic cardiomyopathy (HCM) share clinical and hemodynamic features of left ventricular (LV) hypertrophy and abnormal diastolic function, it is often difficult to distinguish these entities. We investigated the potential role of high-sensitivity cardiac troponin T (hs-cTnT) for differentiation of infiltrative cardiomyopathy from HCM. The study group consisted of 46 consecutive patients with infiltrative cardiomyopathies or HCM in whom sarcomere protein gene mutations were identified at Kochi Medical School Hospital; of these, there were 11 patients with infiltrative cardiomyopathy (cardiac amyloidosis in 8 patients and Fabry disease in 3 patients) and 35 HCM patients. Serum hs-cTnT level was significantly higher in patients who had infiltrative cardiomyopathy than in those who had HCM (0.083 ± 0.057 ng/ml versus 0.027 ± 0.034 ng/ml, p < 0.001), whereas brain natriuretic peptide levels did not differ between the two groups. In two age-matched the 2 cohorts (patients evaluated at > 40 years at age), hs-cTnT level, maximum LV wall thickness, posterior wall thickness, peak early (E) transmitral filling velocity, peak early diastolic (Ea) velocity of tissue Doppler imaging at the lateral corner and E/Ea ratios at both the septal and lateral corners were significantly different between the two groups. As for diagnostic accuracy to differentiate the two groups by using receiver operating characteristic analysis, hs-cTnT was the highest value of area under the curve (0.939) and E/Ea (lateral) was second highest value (0.914). Serum hs-cTnT is a helpful diagnostic indicator for accurate differentiation between infiltrative cardiomyopathy and HCM.
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DOI：
10.1016/s0735-1097(85)80475-7
发表时间：
1985-01-01
影响因子：
24
作者：
CUETOGARCIA, L;REEDER, GS;TAJIK, AJ
通讯作者：
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影响因子：
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作者：
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作者：
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影响因子：
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作者：
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通讯作者：
van Rossum, Albert C.
影响因子：
2.5
作者：
Jenab, Yaser;Pourjafari, Marzieh;Jalali, Arash
通讯作者：
Jalali, Arash