Childhood trauma and children's emerging psychotic symptoms: A genetically sensitive longitudinal cohort study.
Childhood trauma and children's emerging psychotic symptoms: A genetically sensitive longitudinal cohort study.
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DOI：
10.1176/appi.ajp.2010.10040567
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发表时间：
2011-01
期刊：
影响因子：
--
通讯作者：
Caspi A
中科院分区：
文献类型：
--
作者：
Arseneault L;Cannon M;Fisher HL;Polanczyk G;Moffitt TE;Caspi A
通过对儿童时期创伤的纵向和前瞻性测量，作者评估了一组具有全国代表性的英国年轻双胞胎中与虐待、欺凌和事故相关的精神病症状的风险。数据来自环境风险纵向双胞胎研究，该研究追踪了2232名双胞胎儿童及其家庭。在孩子5岁、7岁、10岁和12岁时，对母亲进行家访，询问孩子是否遭受过成年人的虐待、同伴的欺凌或卷入过事故。12岁时，孩子们被问及欺凌经历和精神病症状。儿童报告的精神病症状得到临床医生的证实。经历过成人虐待（相对风险=3.16,95% CI= 1.92-5.19）或同伴欺凌（相对风险=2.47,95% CI= 1.74-3.52）的儿童在12岁时比没有经历过此类创伤事件的儿童更有可能报告精神病症状。无论这些事件发生在生命早期还是在童年后期，出现精神病症状的风险都较高。在控制儿童性别、社会经济剥夺和智商的分析中，与儿童创伤相关的风险仍然显著；针对儿童内化或外化问题的早期症状；以及儿童患精神病的遗传易感性。相比之下，与事故相关的风险较小（相对风险=1.47,95% CI= 1.02-2.13），并且在不同年龄之间不一致。以伤害意图为特征的创伤与儿童报告的精神病症状有关。与报告早期精神病症状的儿童一起工作的临床医生应该询问创伤性事件，如虐待和欺凌。
Using longitudinal and prospective measures of trauma during childhood, the authors assessed the risk of developing psychotic symptoms associated with maltreatment, bullying, and accidents in a nationally representative U.K. cohort of young twins. Data were from the Environmental Risk Longitudinal Twin Study, which follows 2,232 twin children and their families. Mothers were interviewed during home visits when children were ages 5, 7, 10, and 12 on whether the children had experienced maltreatment by an adult, bullying by peers, or involvement in an accident. At age 12, children were asked about bullying experiences and psychotic symptoms. Children’s reports of psychotic symptoms were verified by clinicians. Children who experienced maltreatment by an adult (relative risk=3.16, 95% CI=1.92–5.19) or bullying by peers (relative risk=2.47, 95% CI=1.74–3.52) were more likely to report psychotic symptoms at age 12 than were children who did not experience such traumatic events. The higher risk for psychotic symptoms was observed whether these events occurred early in life or later in childhood. The risk associated with childhood trauma remained significant in analyses controlling for children’s gender, socioeconomic deprivation, and IQ; for children’s early symptoms of internalizing or externalizing problems; and for children’s genetic liability to developing psychosis. In contrast, the risk associated with accidents was small (relative risk=1.47, 95% CI=1.02–2.13) and inconsistent across ages. Trauma characterized by intention to harm is associated with children’s reports of psychotic symptoms. Clinicians working with children who report early symptoms of psychosis should inquire about traumatic events such as maltreatment and bullying.
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DOI：
10.1111/j.1469-7610.1995.tb01366.x
发表时间：
1995-10-01
期刊：
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES
影响因子：
--
作者：
GJONE, H;NOVIK, TS
通讯作者：
NOVIK, TS
影响因子：
8
作者：
Arseneault, L;Walsh, E;Moffitt, TE
通讯作者：
Moffitt, TE
影响因子：
56.9
作者：
DODGE, KA;BATES, JE;PETTIT, GS
通讯作者：
PETTIT, GS
影响因子：
10.5
作者：
Kelleher, Ian;Harley, Michelle;Cannon, Mary
通讯作者：
Cannon, Mary
影响因子：
6.9
作者：
Harley, M.;Kelleher, I.;Cannon, M.
通讯作者：
Cannon, M.