Role of the Lung Microbiome in the Pathogenesis of Chronic Obstructive Pulmonary Disease.
Role of the Lung Microbiome in the Pathogenesis of Chronic Obstructive Pulmonary Disease.
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肺微生物组在慢性阻塞性肺疾病发病机制中的作用
DOI：
10.4103/0366-6999.211452
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发表时间：
2017-09-05
影响因子：
6.1
通讯作者：
Wang C
中科院分区：
文献类型：
--
作者：
Wang L;Hao K;Yang T;Wang C
独立于培养的微生物分析技术的发展表明，健康或慢性阻塞性肺疾病（COPD）个体的支气管树都不是无菌的。随着测序技术的进步，肺微生物组已成为肺部疾病研究的新领域，这种进步使人们更好地了解慢性阻塞性肺病中的肺微生物组。本文旨在总结肺微生物组的最新进展、其与慢性阻塞性肺病的关系以及微生物组促进慢性阻塞性肺病发病的可能机制。使用 PubMed 进行文献检索，收集有关 COPD 肺微生物组的所有可用研究。搜索词是“微生物组”和“慢性阻塞性肺病”，或“微生物组”和“肺/肺”。选用有关肺微生物组或COPD肺微生物组的英文论文，文章类型不限。肺是一个复杂的微生物生态系统；肺部微生物群是支气管树和实质组织中存活和非存活微生物群（细菌、病毒和真菌）的集合，这对健康很重要。以下类型的呼吸道样本通常用于检测肺部微生物组：痰液、支气管吸出物、支气管肺泡灌洗液和支气管粘膜。紊乱的细菌微生物群参与 COPD 的发病机制；在慢性阻塞性肺病恶化期间，微生物群也会发生动态变化。肺微生物组可能通过控制炎症和/或免疫过程促进慢性阻塞性肺病的发病机制。正常的肺微生物组可用于 COPD 的预防或治疗管理，肺微生物组的变化也可作为评估 COPD 的生物标志物。
The development of culture-independent techniques for microbiological analysis shows that bronchial tree is not sterile in either healthy or chronic obstructive pulmonary disease (COPD) individuals. With the advance of sequencing technologies, lung microbiome has become a new frontier for pulmonary disease research, and such advance has led to better understanding of the lung microbiome in COPD. This review aimed to summarize the recent advances in lung microbiome, its relationships with COPD, and the possible mechanisms that microbiome contributed to COPD pathogenesis. Literature search was conducted using PubMed to collect all available studies concerning lung microbiome in COPD. The search terms were “microbiome” and “chronic obstructive pulmonary disease”, or “microbiome” and “lung/pulmonary”. The papers in English about lung microbiome or lung microbiome in COPD were selected, and the type of articles was not limited. The lung is a complex microbial ecosystem; the microbiome in lung is a collection of viable and nonviable microbiota (bacteria, viruses, and fungi) residing in the bronchial tree and parenchymal tissues, which is important for health. The following types of respiratory samples are often used to detect the lung microbiome: sputum, bronchial aspirate, bronchoalveolar lavage, and bronchial mucosa. Disordered bacterial microbiome is participated in pathogenesis of COPD; there are also dynamic changes in microbiota during COPD exacerbations. Lung microbiome may contribute to the pathogenesis of COPD by manipulating inflammatory and/or immune process. Normal lung microbiome could be useful for prophylactic or therapeutic management in COPD, and the changes of lung microbiome could also serve as biomarkers for the evaluation of COPD.
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影响因子：
168.9
作者：
Dickson, Robert P.;Martinez, Fernando J.;Huffnagle, Gary B.
通讯作者：
Huffnagle, Gary B.
影响因子：
3.7
作者：
Erb-Downward JR;Thompson DL;Han MK;Freeman CM;McCloskey L;Schmidt LA;Young VB;Toews GB;Curtis JL;Sundaram B;Martinez FJ;Huffnagle GB
通讯作者：
Huffnagle GB
DOI：
10.2174/1874285801509010167
发表时间：
2015
期刊：
The open microbiology journal
影响因子：
--
作者：
Barfod KK;Vrankx K;Mirsepasi-Lauridsen HC;Hansen JS;Hougaard KS;Larsen ST;Ouwenhand AC;Krogfelt KA
通讯作者：
Krogfelt KA
影响因子：
30.8
作者：
Hobbs BD;de Jong K;Lamontagne M;Bossé Y;Shrine N;Artigas MS;Wain LV;Hall IP;Jackson VE;Wyss AB;London SJ;North KE;Franceschini N;Strachan DP;Beaty TH;Hokanson JE;Crapo JD;Castaldi PJ;Chase RP;Bartz TM;Heckbert SR;Psaty BM;Gharib SA;Zanen P;Lammers JW;Oudkerk M;Groen HJ;Locantore N;Tal-Singer R;Rennard SI;Vestbo J;Timens W;Paré PD;Latourelle JC;Dupuis J;O'Connor GT;Wilk JB;Kim WJ;Lee MK;Oh YM;Vonk JM;de Koning HJ;Leng S;Belinsky SA;Tesfaigzi Y;Manichaikul A;Wang XQ;Rich SS;Barr RG;Sparrow D;Litonjua AA;Bakke P;Gulsvik A;Lahousse L;Brusselle GG;Stricker BH;Uitterlinden AG;Ampleford EJ;Bleecker ER;Woodruff PG;Meyers DA;Qiao D;Lomas DA;Yim JJ;Kim DK;Hawrylkiewicz I;Sliwinski P;Hardin M;Fingerlin TE;Schwartz DA;Postma DS;MacNee W;Tobin MD;Silverman EK;Boezen HM;Cho MH;COPDGene Investigators;ECLIPSE Investigators;LifeLines Investigators;SPIROMICS Research Group;International COPD Genetics Network Investigators;UK BiLEVE Investigators;International COPD Genetics Consortium
通讯作者：
International COPD Genetics Consortium
影响因子：
5.7
作者：
Barnes, Peter J.
通讯作者：
Barnes, Peter J.