Heterosynaptic plasticity in the neocortex.

Heterosynaptic plasticity in the neocortex.
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新皮质的异质突触可塑性。

DOI:
10.1007/s00221-009-1859-5
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发表时间:
2009-12
影响因子:
2
通讯作者:
Volgushev, Maxim
Volgushev, Maxim
中科院分区:
医学4区
文献类型:
--
作者:
Chistiakova, Marina;Volgushev, Maxim

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在一个具有可塑性突触的系统中,持续的学习不断地塑造神经元突触权重的分布。可塑性可以改变诱导-同质突触变化过程中活跃的突触的权重,也可以改变诱导-异质突触变化过程中不活跃的突触。本文认为,异突触可塑性和同突触可塑性是互补的过程,异突触可塑性可能伴随着典型配对协议诱导的同突触可塑性。突触对可塑性变化的易感性并不一致,但具有增强或抑制或不改变的倾向。易感性是决定同突触和异突触变化方向和幅度的因素之一。根据可塑性倾向发生的异突触变化可能为神经元突触权重的内稳态和延长神经元网络持续学习过程中记忆痕迹的寿命提供了有用的机制。
Ongoing learning continuously shapes the distribution of neurons’ synaptic weights in a system with plastic synapses. Plasticity may change the weights of synapses that were active during the induction—homosynaptic changes, but also may change synapses not active during the induction—heterosynaptic changes. Here we will argue, that heterosynaptic and homosynaptic plasticity are complementary processes, and that heterosynaptic plasticity might accompany homosynaptic plasticity induced by typical pairing protocols. Synapses are not uniform in their susceptibility for plastic changes, but have predispositions to undergo potentiation or depression, or not to change. Predisposition is one of the factors determining the direction and magnitude of homo- and heterosynaptic changes. Heterosynaptic changes which take place according to predispositions for plasticity may provide a useful mechanism(s) for homeostasis of neurons’ synaptic weights and extending the lifetime of memory traces during ongoing learning in neuronal networks.
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