Atypical Integration of Sensory-to-Transmodal Functional Systems Mediates Symptom Severity in Autism.
Atypical Integration of Sensory-to-Transmodal Functional Systems Mediates Symptom Severity in Autism.
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DOI：
10.3389/fpsyt.2021.699813
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发表时间：
2021
影响因子：
4.7
通讯作者：
Hong SJ
中科院分区：
文献类型：
--
作者：
Park S;Haak KV;Cho HB;Valk SL;Bethlehem RAI;Milham MP;Bernhardt BC;Di Martino A;Hong SJ
自闭症谱系障碍(ASD)的一个显着特征是低水平感觉加工和高层次社会互动的共同出现的缺陷。虽然有证据表明感觉异常对ASD的高阶认知功能产生不利的级联效应，但其跨皮质的非典型功能相互作用的确切病理机制尚未得到系统的研究。为了解决这一差距，我们在这里评估了ASD感觉和运动区的功能组织，以及它们与皮质下和高阶感觉神经系统的关系。在107名ASD和113名神经典型个体的静息状态fMRI数据中，我们应用先进的连接映射来探索主要感觉/运动区的功能组织，并进行基于种子的定向内在功能连接(IFC)分析。在ASD中，连接标测显示运动和视觉区域的拓扑异常(即过度分离的IFC)，前者的模式与受限和重复行为的症状严重程度有关。此外，基于SEED的分析发现了ASD相关连接性病变的不同模式：感觉/运动区内的IFC减少，但感觉和皮质下结构之间的IFC增加。虽然在高阶功能系统中也发现了IFCs的减少，但这种异常的总体比例沿着皮质层次水平有增加的趋势，这表明在高阶功能网络中有更多的连接障碍。最后，我们证明了ASD的低水平感觉/运动IFC与临床症状之间的关联是由高阶转模系统介导的，这表明沿着皮质层级的致病功能相互作用。这些发现在很大程度上是在独立的数据集中重复的。这些结果强调了感觉到高阶系统的非典型整合导致了复杂的ASD症状。
A notable characteristic of autism spectrum disorder (ASD) is co-occurring deficits in low-level sensory processing and high-order social interaction. While there is evidence indicating detrimental cascading effects of sensory anomalies on the high-order cognitive functions in ASD, the exact pathological mechanism underlying their atypical functional interaction across the cortical hierarchy has not been systematically investigated. To address this gap, here we assessed the functional organisation of sensory and motor areas in ASD, and their relationship with subcortical and high-order trandmodal systems. In a resting-state fMRI data of 107 ASD and 113 neurotypical individuals, we applied advanced connectopic mapping to probe functional organization of primary sensory/motor areas, together with targeted seed-based intrinsic functional connectivity (iFC) analyses. In ASD, the connectopic mapping revealed topological anomalies (i.e., excessively more segregated iFC) in the motor and visual areas, the former of which patterns showed association with the symptom severity of restricted and repetitive behaviors. Moreover, the seed-based analysis found diverging patterns of ASD-related connectopathies: decreased iFCs within the sensory/motor areas but increased iFCs between sensory and subcortical structures. While decreased iFCs were also found within the higher-order functional systems, the overall proportion of this anomaly tends to increase along the level of cortical hierarchy, suggesting more dysconnectivity in the higher-order functional networks. Finally, we demonstrated that the association between low-level sensory/motor iFCs and clinical symptoms in ASD was mediated by the high-order transmodal systems, suggesting pathogenic functional interactions along the cortical hierarchy. Findings were largely replicated in the independent dataset. These results highlight that atypical integration of sensory-to-high-order systems contributes to the complex ASD symptomatology.
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影响因子：
6.7
作者：
Baum SH;Stevenson RA;Wallace MT
通讯作者：
Wallace MT
影响因子：
11
作者：
Di Martino, A.;Yan, C-G;Li, Q.;Denio, E.;Castellanos, F. X.;Alaerts, K.;Anderson, J. S.;Assaf, M.;Bookheimer, S. Y.;Dapretto, M.;Deen, B.;Delmonte, S.;Dinstein, I.;Ertl-Wagner, B.;Fair, D. A.;Gallagher, L.;Kennedy, D. P.;Keown, C. L.;Keysers, C.;Lainhart, J. E.;Lord, C.;Luna, B.;Menon, V.;Minshew, N. J.;Monk, C. S.;Mueller, S.;Mueller, R. A.;Nebel, M. B.;Nigg, J. T.;O'Hearn, K.;Pelphrey, K. A.;Peltier, S. J.;Rudie, J. D.;Sunaert, S.;Thioux, M.;Tyszka, J. M.;Uddin, L. Q.;Verhoeven, J. S.;Wenderoth, N.;Wiggins, J. L.;Mostofsky, S. H.;Milham, M. P.
通讯作者：
Milham, M. P.
影响因子：
3.9
作者：
Boyd, Brian A.;McDonough, Stephen G.;Bodfish, James W.
通讯作者：
Bodfish, James W.
DOI：
10.3758/bf03208380
发表时间：
1995-11-01
期刊：
PERCEPTION & PSYCHOPHYSICS
影响因子：
--
作者：
CARRASCO, M;EVERT, DL;KATZ, SM
通讯作者：
KATZ, SM
影响因子：
4.7
作者：
Damiano-Goodwin, Cara R.;Woynaroski, Tiffany G.;Cascio, Carissa J.
通讯作者：
Cascio, Carissa J.