Sex and gender in psychoneuroimmunology research: past, present and future.

Sex and gender in psychoneuroimmunology research: past, present and future.
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DOI:
10.1016/j.bbi.2009.02.019
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发表时间:
2009-07
影响因子:
15.1
通讯作者:
Suarez, Edward C.
Suarez, Edward C.
中科院分区:
医学1区
文献类型:
--
作者:
Darnall, Beth D.;Suarez, Edward C.

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到目前为止,研究表明,性别和性别的影响途径中央的焦点心理神经免疫学(PNI)。本文对心理神经免疫学研究中的性和性别的演变进行了历史回顾。性别和性二态途径可能对男性和女性的健康差异产生协同效应。我们提供了一个概述的性别和性别差异的大脑结构和功能,性类固醇,性别角色识别,下丘脑-垂体-肾上腺轴功能,遗传学,免疫学和细胞因子反应的文献。提供了具体的例子,说明在《国家行动计划》的研究和建议中重视性和性别方法的重要性。
To date, research suggests that sex and gender impact pathways central to the foci of psychoneuroimmunology (PNI). This review provides a historical perspective on the evolution of sex and gender in psychoneuroimmunology research. Gender and sexually dimorphic pathways may have synergistic effects on health differences in men and women. We provide an overview of the literature of sex and gender differences in brain structure and function, sex steroids, gender role identification, hypothalamic-pituitary-adrenal axis function, genetics, immunology and cytokine response. Specific examples shed light on the importance of attending to sex and gender methodology in PNI research and recommendations are provided.
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