Dietary and inhalation exposure to polycyclic aromatic hydrocarbons and urinary excretion of monohydroxy metabolites--a controlled case study in Beijing, China.
Dietary and inhalation exposure to polycyclic aromatic hydrocarbons and urinary excretion of monohydroxy metabolites--a controlled case study in Beijing, China.
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DOI：
10.1016/j.envpol.2013.10.005
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发表时间：
2014-01
影响因子：
8.9
通讯作者：
Tao, Shu
中科院分区：
文献类型：
--
作者：
Zhang, Yanyan;Ding, Junnan;Shen, Guofeng;Zhong, Junjun;Wang, Chen;Wei, Siye;Chen, Chaoqi;Chen, Yuanchen;Lu, Yan;Shen, Huizhong;Li, Wei;Huang, Ye;Chen, Han;Su, Shu;Lin, Nan;Wang, Long;Liu, Wenxin;Tao, Shu
在一项受控喂养实验中，对中国北京 12 名不吸烟的大学生进行了每日饮食和吸入 16 种多环芳烃 (PAH) 暴露量以及 13 种单羟基代谢物 (OHPAH) 尿排泄量的监测。研究了 OHPAH 的尿液排泄与 PAH 的摄取之间的关系。结果表明，受试者通过饮食和吸入途径严重接触多环芳烃。大多数尿中 OHPAH 的大量增加发生在摄入烤羊肉后。女性受试者的 OHPAH 浓度较高，其父母 PAH 的摄入量低于男性，这可能是由于新陈代谢方面的性别差异。看来，除了 1-PYR 之外，PHE 的代谢物也可以用作指示短期膳食暴露于 PAHs 的生物标志物，而尿液 3-BaA 可以作为吸入摄入高分子量 PAHs 的生物标志物。
Daily dietary and inhalation exposures to 16 parent polycyclic aromatic hydrocarbons (PAHs) and urinary excretion of 13 monohydroxy metabolites (OHPAHs) were monitored for 12 non-smoking university students in Beijing, China, during a controlled feeding experiment. The relationship between the urinary excretion of OHPAHs and the uptake of PAHs was investigated. The results suggest severe exposure of the subjects to PAHs via both dietary and inhalation pathways. Large increase of most urinary OHPAHs occurred after the ingestion of lamb kabob. Higher concentrations of OHPAHs were observed for female subjects, with the intakes of parent PAHs lower than those by males, likely due to the gender differences in metabolism. It appears that besides 1-PYR, metabolites of PHE could also be used as biomarkers to indicate the short-term dietary exposure to PAHs and urinary 3-BaA may serve as the biomarker for inhalation intake of high molecular weight PAHs.
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DOI：
10.1007/bf00383545
发表时间：
1985-01-01
影响因子：
3
作者：
JONGENEELEN, FJ;ANZION, RBM;HENDERSON, PT
通讯作者：
HENDERSON, PT
影响因子：
5.6
作者：
Cocco, Pierluigi;Moore, Patrick S.;Flore, Costantino
通讯作者：
Flore, Costantino
影响因子：
11.8
作者：
Martorell, Isabel;Perello, Gemma;Domingo, Jose L.
通讯作者：
Domingo, Jose L.
影响因子：
6
作者：
Alomirah, Husam;Al-Zenki, Sameer;Kannan, Kurunthachalam
通讯作者：
Kannan, Kurunthachalam
影响因子：
8.3
作者：
Li, Zheng;Sandau, Courtney D.;Patterson, Donald G., Jr.
通讯作者：
Patterson, Donald G., Jr.