Identification of burden hotspots and risk factors for cholera in India: An observational study.
Identification of burden hotspots and risk factors for cholera in India: An observational study.
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识别印度霍乱的负担热点和危险因素：一项观察性研究。
DOI：
10.1371/journal.pone.0183100
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Ganguly NK
中科院分区：
文献类型：
--
作者：
Ali M;Sen Gupta S;Arora N;Khasnobis P;Venkatesh S;Sur D;Nair GB;Sack DA;Ganguly NK
尽管霍乱已经存在了几个世纪，该国许多地区都有零星的地方性和流行性霍乱，但它仍然是印度一个未被认识到的健康问题。该国成立了一个霍乱专家组，以收集证据，并制定印度霍乱控制路线图。本文确定了霍乱负担热点和与疾病风险增加相关的因素。我们从综合疾病监测计划获得了2010-2015年霍乱病例报告的地区数据。从2011年人口普查中获得了水和卫生设施的社会经济特征和覆盖面。进行空间分析，以确定霍乱热点，并采用零膨胀泊松回归，以确定与霍乱和预测的病例数在该地区的因素。在这6年期间，报告了27 615例霍乱病例。在这些年里，印度36个邦中有24个邦报告了霍乱，13个邦被列为地方病。在641个区中，15个州的78个区根据报告的病例被确定为“热点”。另一方面，根据基于模型的预测病例数，9个州的111个地区被确定为“热点”。一个地区的霍乱风险与识字人口、使用处理水源的家庭和拥有移动的电话的覆盖率呈负相关，与该地区卫生和排水条件差的覆盖率和城市化水平呈正相关。该研究重申，霍乱继续在印度大部分地区发生，并确定了负担热点和风险因素。政策制定者可以利用这篇文章的发现来制定印度霍乱预防和控制的路线图。
Even though cholera has existed for centuries and many parts of the country have sporadic, endemic and epidemic cholera, it is still an under-recognized health problem in India. A Cholera Expert Group in the country was established to gather evidence and to prepare a road map for control of cholera in India. This paper identifies cholera burden hotspots and factors associated with an increased risk of the disease. We acquired district level data on cholera case reports of 2010–2015 from the Integrated Disease Surveillance Program. Socioeconomic characteristics and coverage of water and sanitation was obtained from the 2011 census. Spatial analysis was performed to identify cholera hotspots, and a zero-inflated Poisson regression was employed to identify the factors associated with cholera and predicted case count in the district. 27,615 cholera cases were reported during the 6-year period. Twenty-four of 36 states of India reported cholera during these years, and 13 states were classified as endemic. Of 641 districts, 78 districts in 15 states were identified as “hotspots” based on the reported cases. On the other hand, 111 districts in nine states were identified as “hotspots” from model-based predicted number of cases. The risk for cholera in a district was negatively associated with the coverage of literate persons, households using treated water source and owning mobile telephone, and positively associated with the coverage of poor sanitation and drainage conditions and urbanization level in the district. The study reaffirms that cholera continues to occur throughout a large part of India and identifies the burden hotspots and risk factors. Policymakers may use the findings of the article to develop a roadmap for prevention and control of cholera in India.
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影响因子：
4.5
作者：
Sundaram N;Schaetti C;Merten S;Schindler C;Ali SM;Nyambedha EO;Lapika B;Chaignat CL;Hutubessy R;Weiss MG
通讯作者：
Weiss MG
影响因子：
12.7
作者：
Kulldorff, M;Athas, WF;Key, CR
通讯作者：
Key, CR
影响因子：
4.8
作者：
Leckebusch, Gregor C.;Abdussalam, Auwal F.
通讯作者：
Abdussalam, Auwal F.
影响因子：
11.4
作者：
Sobsey, Mark D.;Stauber, Christine E.;Elliott, Mark A.
通讯作者：
Elliott, Mark A.
DOI：
10.4269/ajtmh.16-0427
发表时间：
2017-06
期刊：
The American journal of tropical medicine and hygiene
影响因子：
--
作者：
Lessler J;Azman AS;McKay HS;Moore SM
通讯作者：
Moore SM