Subiculum as a generator of sharp wave-ripples in the rodent hippocampus.
Subiculum as a generator of sharp wave-ripples in the rodent hippocampus.
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DOI：
10.1016/j.celrep.2021.109021
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发表时间：
2021-04-20
期刊：
影响因子：
8.8
通讯作者：
Schmitz, Dietmar
中科院分区：
文献类型：
--
作者：
Imbrosci, Barbara;Nitzan, Noam;McKenzie, Sam;Donoso, Jose R.;Swaminathan, Aarti;Bohm, Claudia;Maier, Nikolaus;Schmitz, Dietmar
尖波波纹（SWR）代表海马神经元的同步放电，并被认为在记忆巩固中发挥重要作用。大量的证据表明，SWR是专门产生的CA 3-CA 2网络。与此相反，在这里，我们提供了几条线的证据表明，下托可以作为一个次级驻波发生器。下托起源的SWRs向前传播到内嗅皮层以及向后传播到海马。我们的研究结果表明，海马的输出结构不仅被动地促进了SWRs向皮层的转移，但它们也可以积极地促进SWRs的发生。我们推测，与一个subicular起源的SWR可能是重要的巩固信息传达到海马通过temporoammonic途径。Imbrosci等人的研究表明，下托可以作为一个次级发生器，产生尖锐的波纹（SWR）。起源于下托的SWRs可以传播到内嗅皮层，并向后传播到CA 1和CA 3。
Sharp wave-ripples (SWRs) represent synchronous discharges of hippocampal neurons and are believed to play a major role in memory consolidation. A large body of evidence suggests that SWRs are exclusively generated in the CA3-CA2 network. In contrast, here, we provide several lines of evidence showing that the subiculum can function as a secondary SWRs generator. SWRs with subicular origin propagate forward into the entorhinal cortex as well as backward into the hippocampus proper. Our findings suggest that the output structures of the hippocampus are not only passively facilitating the transfer of SWRs to the cortex, but they also can actively contribute to the genesis of SWRs. We hypothesize that SWRs with a subicular origin may be important for the consolidation of information conveyed to the hippocampus via the temporoammonic pathway. Imbrosci et al. show that the subiculum can work as a secondary generator of sharp wave-ripples (SWRs). SWRs with their origin in subiculum can propagate to the entorhinal cortex and backward to CA1 and CA3.
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DOI：
10.1126/science.aan6203
发表时间：
2017-10-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Khodagholy D;Gelinas JN;Buzsáki G
通讯作者：
Buzsáki G
影响因子：
25
作者：
Girardeau, Gabrielle;Benchenane, Karim;Zugaro, Michael B.
通讯作者：
Zugaro, Michael B.
影响因子：
25
作者：
Ji, Daoyun;Wilson, Matthew A.
通讯作者：
Wilson, Matthew A.
影响因子：
16.2
作者：
Isomura, Yoshikazu;Sirota, Anton;Buzsaki, Gyoergy
通讯作者：
Buzsaki, Gyoergy
影响因子：
2.9
作者：
BUZSAKI, G
通讯作者：
BUZSAKI, G