Localization of HB9 homeobox gene mRNA and protein during the early stages of chick feather development.
Localization of HB9 homeobox gene mRNA and protein during the early stages of chick feather development.
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鸡羽毛发育早期阶段 HB9 同源盒基因 mRNA 和蛋白质的定位。
DOI：
10.1006/bbrc.2000.3523
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发表时间：
2000
影响因子：
3.1
通讯作者：
H. Hirano
中科院分区：
文献类型：
--
作者：
Y. Kosaka;Y. Akimoto;A. Obinata;H. Hirano
我们分别对鸡毛发育过程中HB9同源框基因的mRNA和蛋白进行了原位杂交和免疫组织化学分析。HB9基因在羽毛和胎盘的表皮基底层细胞和真皮细胞中高表达，而在胎盘和羽芽间区不表达。HB9蛋白主要在对称短芽的真皮细胞中表达，当羽芽沿前-后(A-P)和近-远(P-D)轴伸长时，在不对称蕾期后表达减弱。这些结果表明，HB9基因在羽毛发育过程中受到时空调控，可能参与了羽芽的早期形态发生。
We performed in situ hybridization and immunohistochemical analysis of HB9 homeobox gene mRNA and protein, respectively, during chick feather development. HB9 mRNA was highly expressed in epidermal basal cells and dermal cells of the placodes and feather buds, but not in those of the interplacodes and interbud regions. HB9 protein was predominantly expressed in dermal cells of the symmetric short buds and decreased after the asymmetric bud stage when the feather bud had become elongated along the anterior-posterior (A-P) and proximal-distal (P-D) axis. These results suggest that HB9 gene is regulated in a spatiotemporal manner during feather development, and may be involved in early feather bud morphogenesis.
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