How can dementia and disability be prevented in older adults: where are we today and where are we going?
How can dementia and disability be prevented in older adults: where are we today and where are we going?
复制标题
如何在老年人中预防痴呆和残疾：我们今天在哪里，我们将向哪里发展？
DOI：
10.1111/joim.13227
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发表时间：
2021-06
影响因子：
11.1
通讯作者：
Kivipelto M
中科院分区：
文献类型：
--
作者：
Lisko I;Kulmala J;Annetorp M;Ngandu T;Mangialasche F;Kivipelto M
人口老龄化，加上人口增长，导致患有痴呆症和残疾的老年人人数大量增加。痴呆症是老年人残疾的主要原因，促进大脑健康老龄化被认为是减轻与年龄相关的残疾负担的关键因素。世界卫生组织最近发布了首个认知障碍和痴呆症风险降低指南。根据最近的估计，全世界大约40%的痴呆症病例可归因于12个可改变的危险因素：低教育；中年高血压和肥胖症；糖尿病、吸烟、过度饮酒、缺乏体育活动、抑郁、低社交、听力丧失、创伤性脑损伤和空气污染，表明有明显的预防潜力。痴呆症和肢体残疾与共同的风险因素和支持综合预防干预的可能性的可能共同的潜在机制密切相关。Finger试验是第一个大型随机对照试验，表明基于多领域生活方式的干预可以防止普通人群中高危老年人的认知和功能下降。在全球手指网络内，多领域手指概念现已在全世界范围内得到测试和调整，证明了有效和易于实施的预防战略的证据和工具。需要研究人员、政策制定者和医疗从业者之间的密切合作，老年人的参与和利用新技术来支持自我管理，以促进研究结果的实施。在这一范围回顾中，我们提出了痴呆症和残疾预防领域目前的科学证据，并讨论了该领域的未来方向。
Ageing of the population, together with population growth, has brought along an ample increase in the number of older individuals living with dementia and disabilities. Dementia is the main cause of disability in old age, and promoting healthy brain ageing is considered as a key element in diminishing the burden of age‐related disabilities. The World Health Organization recently launched the first risk reduction guidelines for cognitive impairment and dementia. According to recent estimates, approximately 40% of dementia cases worldwide could be attributable to 12 modifiable risk factors: low education; midlife hypertension and obesity; diabetes, smoking, excessive alcohol use, physical inactivity, depression, low social contact, hearing loss, traumatic brain injury and air pollution indicating clear prevention potential. Dementia and physical disability are closely linked with shared risk factors and possible shared underlying mechanisms supporting the possibility of integrated preventive interventions. FINGER trial was the first large randomized controlled trial indicating that multidomain lifestyle‐based intervention can prevent cognitive and functional decline amongst at‐risk older adults from the general population. Within the World‐Wide FINGERS network, the multidomain FINGER concept is now tested and adapted worldwide proving evidence and tools for effective and easily implementable preventive strategies. Close collaboration between researchers, policymakers and healthcare practitioners, involvement of older adults and utilization of new technologies to support self‐management is needed to facilitate the implementation of the research findings. In this scoping review, we present the current scientific evidence in the field of dementia and disability prevention and discuss future directions in the field.
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影响因子：
168.9
作者：
Christensen, Kaare;Doblhammer, Gabriele;Rau, Roland;Vaupel, James W.
通讯作者：
Vaupel, James W.
DOI：
10.1016/j.dadm.2017.05.007
发表时间：
2017
期刊：
Alzheimer's & dementia (Amsterdam, Netherlands)
影响因子：
--
作者：
Albanese E;Launer LJ;Egger M;Prince MJ;Giannakopoulos P;Wolters FJ;Egan K
通讯作者：
Egan K
影响因子：
11.2
作者：
Bennett, David A.;Wilson, Robert S.;Boyle, Patricia A.;Buchman, Aron S.;Schneider, Julie A.
通讯作者：
Schneider, Julie A.
影响因子：
120.7
作者：
Ball, K;Berch, DB;Willis, SL
通讯作者：
Willis, SL
DOI：
10.1093/gerona/glu207
发表时间：
2015-05-01
影响因子：
5.1
作者：
Chen, David S.;Betz, Joshua;Lin, Frank R.
通讯作者：
Lin, Frank R.