Deficits in attentional modulation of auditory N100 in first-episode schizophrenia.
Deficits in attentional modulation of auditory N100 in first-episode schizophrenia.
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DOI：
10.1111/ejn.15128
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发表时间：
2021-04
影响因子：
3.4
通讯作者：
Salisbury, Dean F.
中科院分区：
文献类型：
--
作者：
Ren, Xi;Fribance, Sarah N.;Coffman, Brian A.;Salisbury, Dean F.
听觉N100的减少存在于精神分裂症中，甚至在第一次发作时（FESz）。由于大多数研究检查听觉N100的主动目标检测古怪的任务，目前还不清楚，如果FESz的异常导致感官缺陷或N100的选择性注意增强受损或两者兼而有之。N100记录从21 FESz和22匹配的健康对照（HC）的单音任务和双音oddball任务。总体而言，FESz的N100较小（p=.036）。注意力增强N100振幅（p<.001），但这在组间存在差异，FESz在N100调制中受损（x组注意力，p=.012）。在两组中，oddball任务的N100增强均大于单音任务（p<0.001）。在oddball任务中N100增强的组间差异较大（Cohen's d=0.85）。探索性相关性表明，在FESz中，N100在古怪任务上的增强与更好的MATRICS总体综合评分（对精神病高度敏感的认知任务）、较低的PANS阴性因子和SANS评分以及去年更好的人际（社会）和角色功能相关。忽略条件下的N100显示组间无显著差异，尽管FESz较小，具有小至中等效应量。虽然N100的感觉缺陷可能存在，但由于注意力无法增强N100而使其变得更加复杂。注意力增益控制在FESz中N100增强的失败表明认知控制区和感觉皮层之间的功能障碍。主动注意任务的N100振幅可能是一个有用的结果生物标志物，有针对性地增强认知控制系统。
Reductions of the auditory N100 are present in schizophrenia, even at the first episode (FESz). Because most studies examine auditory N100 on active target detection oddball tasks, it is unclear if the abnormality in FESz results from sensory deficits or impaired enhancement of N100 by selective attention or both. N100 was recorded from 21 FESz and 22 matched healthy controls (HC) on a single-tone task and a two-tone oddball task. Overall, N100 was smaller in FESz (p=.036). Attention enhanced N100 amplitude (p<.001), but this differed between groups, with FESz impaired in N100 modulation (group x attention, p=.012). The oddball task showed greater N100 enhancement than the single-tone task (p<.001) in both groups. Group differences in N100 enhancement in the oddball task were large (Cohen’s d=0.85). Exploratory correlations showed that better N100 enhancement on the oddball task in FESz was associated with better MATRICS Overall Composite scores (cognitive tasks highly sensitive to psychosis), lower PANNS Negative factor and SANS scores, and better interpersonal (social) and role functioning in the last year. N100 during ignore conditions showed no significant difference between groups, albeit smaller in FESz, with small to medium effect sizes. Although sensory deficits in N100 are likely present, they are compounded by a failure to enhance N100 with attention. The failure of N100 enhancement by attentional gain control in FESz suggests functional dysconnection between cognitive control areas and sensory cortex. N100 amplitude on active attention tasks may be a useful outcome biomarker for targeted enhancement of the cognitive control system.
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影响因子：
3.4
作者：
Ren, Xi;Fribance, Sarah N.;Coffman, Brian A.;Salisbury, Dean F.
通讯作者：
Salisbury, Dean F.
影响因子：
5.7
作者：
Asami, Takeshi;Bouix, Sylvain;Whitford, Thomas J.;Shenton, Martha E.;Salisbury, Dean F.;McCarley, Robert W.
通讯作者：
McCarley, Robert W.
影响因子：
6.9
作者：
Kantrowitz, J. T.;Hoptman, M. J.;Leitman, D. I.;Silipo, G.;Javitt, D. C.
通讯作者：
Javitt, D. C.
影响因子：
11.3
作者：
Boutros, NN;Korzyukov, O;Bell, M
通讯作者：
Bell, M
DOI：
10.1177/155005949402500204
发表时间：
1994-04-01
期刊：
CLINICAL ELECTROENCEPHALOGRAPHY
影响因子：
--
作者：
IWANAMI, A;SUGA, I;KANAMORI, R
通讯作者：
KANAMORI, R