The Role and Implications of Epicardial Fat in Coronary Atherosclerotic Disease.
The Role and Implications of Epicardial Fat in Coronary Atherosclerotic Disease.
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DOI：
10.3390/jcm11164718
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发表时间：
2022-08-12
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
--
作者：
目前的小综述旨在评估心外膜脂肪分泌功能在冠状动脉疾病发展中的意义。心外膜脂肪组织(EAT)是一种内脏脂肪库，已被描述为心血管危险因素。除了其机械保护作用和生理分泌功能外，心外膜脂肪的各种分泌产物似乎还负责心肌水平的代谢紊乱，当与先前存在的病理情况有关时，如代谢综合征。与心外膜脂肪组织异常水平相关的肌节缩短、细胞内钙异常流动、肌浆内质网ATPase 2a表达减少和胰岛素介导的Akt-Ser473-磷酸化降低是病理性的。激活素A、血管生成素-2和CD14阳性单核细胞选择性地聚集在病变心肌中，导致心肌细胞收缩功能降低。同时，据认为，分泌产物的这些变化通过分子变化直接降低心肌细胞的功能，从而在某些并存的情况下导致冠状动脉疾病的发生。
The current minireview aims to assess the implications of epicardial fat secretory function in the development of coronary artery disease. The epicardial adipose tissue (EAT) is a visceral fat depot that has been described as a cardiovascular risk factor. In addition to its mechanical protection role and physiological secretory function, it seems that various secretion products of the epicardial fat are responsible for metabolic disturbances at the level of the cardiac muscle when in association with pre-existing pathological conditions, such as metabolic syndrome. There is a pathological reduction in sarcomere shortening, abnormal cytosolic Ca2+ fluxes, reduced expression of sarcoplasmic endoplasmic reticulum ATPase 2a and decreased insulin-mediated Akt-Ser473-phosphorylation in association with abnormal levels of epicardial fat tissue. Activin A, angiopoietin-2, and CD14-positive monocytes selectively accumulate in the diseased myocardium, resulting in reduced cardiomyocyte contractile function. At the same time, it is believed that these alterations in secretory products directly decrease the myocyte function via molecular changes, thus contributing to the development of coronary disease when certain comorbidities are associated.
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影响因子：
1.6
作者：
Hendricks S;Dykun I;Balcer B;Totzeck M;Rassaf T;Mahabadi AA
通讯作者：
Mahabadi AA
影响因子：
3.7
作者：
Corradi, D;Maestri, R;Bordi, C
通讯作者：
Bordi, C
影响因子：
5.3
作者：
Gorter, Petra M.;van Lindert, Anne S. R.;Visseren, Frank L. J.
通讯作者：
Visseren, Frank L. J.
DOI：
10.1016/j.numecd.2008.05.002
发表时间：
2009-03-01
影响因子：
3.9
作者：
Eroglu, S.;Sade, L. E.;Muderrisoglu, H.
通讯作者：
Muderrisoglu, H.
影响因子：
37.8
作者：
Mazurek, T;Zhang, LF;Shi, Y
通讯作者：
Shi, Y