Bone-conduction hyperacusis induced by superior canal dehiscence in human: the underlying mechanism.
Bone-conduction hyperacusis induced by superior canal dehiscence in human: the underlying mechanism.
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DOI：
10.1038/s41598-020-73565-4
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发表时间：
2020-10-06
影响因子：
4.6
通讯作者：
Nakajima HH
中科院分区：
文献类型：
--
作者：
Guan X;Cheng YS;Galaiya DJ;Rosowski JJ;Lee DJ;Nakajima HH
我们通过骨传导(BC)进行听力的能力早已被认识到，但其潜在的机制却知之甚少。为什么某些干扰会影响BC的听力也不清楚。一个例子是BC听力亢进(BC听力超敏)--上神经管裂开(SCD)患者经历的一种令人不安的症状。我们在身体耳的耳蜗基底部测量了BC诱发的前庭阶声压(Psv)和鼓阶声压(Pst)，并用耳蜗声输入驱动(PDIFF、 = 、Psv、 - 、Pst)评估听力。与临床听力图一致，SCD在1 kHz以下增加了BC驱动的PDIFF。然而，SCD以意想不到的方式影响个体的鳞片压力：SCD增加了1 kHz以下的PSV，但对PST几乎没有影响。这些新发现与一些人用来解释BC听力亢进的内耳压迫机制不一致。建立了基于内耳流体惯性机理的计算BC模型，模拟结果与实验结果基本一致。这一实验模拟研究表明：(1)内耳液体惯性是BC听力的一个重要机制；(2)SCD在低频下促进声体积速度通过耳蜗区，导致BC听力亢进。
Our ability to hear through bone conduction (BC) has long been recognized, but the underlying mechanism is poorly understood. Why certain perturbations affect BC hearing is also unclear. An example is BC hyperacusis (hypersensitive BC hearing)—an unnerving symptom experienced by patients with superior canal dehiscence (SCD). We measured BC-evoked sound pressures in scala vestibuli (PSV) and scala tympani (PST) at the basal cochlea in cadaveric human ears, and estimated hearing by the cochlear input drive (PDIFF = PSV – PST) before and after creating an SCD. Consistent with clinical audiograms, SCD increased BC-driven PDIFF below 1 kHz. However, SCD affected the individual scalae pressures in unexpected ways: SCD increased PSV below 1 kHz, but had little effect on PST. These new findings are inconsistent with the inner-ear compression mechanism that some have used to explain BC hyperacusis. We developed a computational BC model based on the inner-ear fluid-inertia mechanism, and the simulated effects of SCD were similar to the experimental findings. This experimental-modeling study suggests that (1) inner-ear fluid inertia is an important mechanism for BC hearing, and (2) SCD facilitates the flow of sound volume velocity through the cochlear partition at low frequencies, resulting in BC hyperacusis.
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影响因子：
1.6
作者：
Pisano DV;Niesten ME;Merchant SN;Nakajima HH
通讯作者：
Nakajima HH
影响因子：
2.8
作者：
Kim, Namkeun;Steele, Charles R.;Puria, Sunil
通讯作者：
Puria, Sunil
影响因子：
2.4
作者：
Olson, ES
通讯作者：
Olson, ES
影响因子：
2.8
作者：
Frear DL;Guan X;Stieger C;Rosowski JJ;Nakajima HH
通讯作者：
Nakajima HH
DOI：
10.1159/000323574
发表时间：
2011-01-01
期刊：
IMPLANTABLE BONE CONDUCTION HEARING AIDS
影响因子：
--
作者：
Stenfelt, Stefan
通讯作者：
Stenfelt, Stefan