Unconditioned responses and functional fear networks in human classical conditioning.
Unconditioned responses and functional fear networks in human classical conditioning.
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DOI：
10.1016/j.bbr.2011.02.045
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发表时间：
2011-08-01
影响因子：
2.7
通讯作者：
Milad, Mohammed R.
中科院分区：
文献类型：
--
作者：
Linnman, Clas;Rougemont-Buecking, Ansgar;Beucke, Jan Carl;Zeffiro, Thomas A.;Milad, Mohammed R.
研究恐惧条件反射的人类成像研究主要集中在对条件线索的神经反应上。相比之下，无条件反应的神经基础和恐惧调节区域间功能耦合的机制受到了有限的关注。我们使用部分强化恐惧条件反射范式和功能磁共振成像检查了对非条件刺激的神经反应。分析的重点是：（1）非条件刺激（电击）的影响，无论是预期和实际交付，或预期，但没有交付，（2）在相关的大脑活动如何改变条件试验，（3）如何冲击预期影响区域间耦合的恐惧网络。我们发现：（1）电击的传递涉及红核、杏仁核、背侧纹状体、杏仁核、躯体感觉和扣带皮层，（2）当预期电击但未传递时，只有红核、前岛和背侧前扣带皮层显示出在试验中持续的活动增加，（3）心理-生理交互作用分析表明，恐惧导致红核与丘脑的耦合增加，而海马与红核、丘脑和小脑的耦合减少。海马体和前额叶可能作为枢纽，促进防御性立即恐惧网络和静息网络之间的转换。
Human imaging studies examining fear conditioning have mainly focused on the neural responses to conditioned cues. In contrast, the neural basis of the unconditioned response and the mechanisms by which fear modulates inter-regional functional coupling have received limited attention. We examined the neural responses to an unconditioned stimulus using a partial-reinforcement fear conditioning paradigm and functional MRI. The analysis focused on: (1) the effects of an unconditioned stimulus (an electric shock) that was either expected and actually delivered, or expected but not delivered, and (2) on how related brain activity changed across conditioning trials, and (3) how shock expectation influenced inter-regional coupling within the fear network. We found that: (1) the delivery of the shock engaged the red nucleus, amygdale, dorsal striatum, insula, somatosensory and cingulate cortices, (2) when the shock was expected but not delivered, only the red nucleus, the anterior insular and dorsal anterior cingulate cortices showed activity increases that were sustained across trials, and (3) psycho-physiological interaction analysis demonstrated that fear led to increased red nucleus coupling to insula but decreased hippocampus coupling to the red nucleus, thalamus and cerebellum. The hippocampus and the anterior insula may serve as hubs facilitating the switch between engagement of a defensive immediate fear network and a resting network.
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DOI：
10.1073/pnas.160266497
发表时间：
2000-08-01
影响因子：
11.1
作者：
Ploghaus, A;Tracey, I;Matthews, PM
通讯作者：
Matthews, PM
影响因子：
2
作者：
Burman, MA;Gewirtz, JC
通讯作者：
Gewirtz, JC
影响因子：
3.5
作者：
FANSELOW, MS
通讯作者：
FANSELOW, MS
创伤后应激障碍中未能回忆灭绝记忆的神经生物学基础。
影响因子：
10.6
作者：
Milad, Mohammed R.;Pitman, Roger K.;Ellis, Cameron B.;Gold, Andrea L.;Shin, Lisa M.;Lasko, Natasha B.;Zeidan, Mohamed A.;Handwerger, Kathryn;Orr, Scott P.;Rauch, Scott L.
通讯作者：
Rauch, Scott L.
DOI：
10.1111/j.1460-9568.2009.06624.x
发表时间：
2009-02
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Lang S;Kroll A;Lipinski SJ;Wessa M;Ridder S;Christmann C;Schad LR;Flor H
通讯作者：
Flor H