Undifferentiated primate spermatogonia and their endocrine control.
Undifferentiated primate spermatogonia and their endocrine control.
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DOI：
10.1016/j.tem.2010.03.001
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发表时间：
2010-08
影响因子：
10.9
通讯作者：
Plant, Tony M.
中科院分区：
文献类型：
--
作者：
Plant, Tony M.
精原干细胞的生物学是目前研究的热点，灵长类动物的研究也在不断涌现。灵长类动物睾丸对精子输出的定量调节似乎主要是在未分化精原细胞向分化精原细胞的转变过程中发挥作用。本文综述了我们对雄性灵长类动物精原细胞更新和早期分化机制的理解的最新进展，重点是猴子。对深色和浅色A型精原细胞分别作为储备和更新精原干细胞的经典观点的新修订进行了批判性评估，并讨论了灵长类动物出生后发育过程中未分化精原细胞内分泌控制的基本特征。在获得更全面的了解灵长类精原细胞障碍也确定。
The biology of spermatogonial stem cells is currently an area of intensive research, and contemporary studies in primates are emerging. Quantitative regulation of sperm output by the primate testis appears to be exerted primarily on the transition from undifferentiated to differentiating spermatogonia. This review examines recent advances in our understanding of the mechanisms governing spermatogonial renewal and early differentiation in male primates, with a focus on the monkey. Emerging revisions to the classic view of dark and pale type A spermatogonia as reserve and renewing spermatogonial stem cells, respectively, are critically evaluated, and essential features of endocrine control of undifferentiated spermatogonia throughout postnatal primate development are discussed. Obstacles in gaining a more complete understanding of primate spermatogonia are also identified.
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