The many facets of the matricelluar protein periostin during cardiac development, remodeling, and pathophysiology.
The many facets of the matricelluar protein periostin during cardiac development, remodeling, and pathophysiology.
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DOI：
10.1007/s12079-009-0063-5
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发表时间：
2009-12
影响因子：
4.1
通讯作者：
Markwald RR
中科院分区：
文献类型：
--
作者：
Norris RA;Moreno-Rodriguez R;Hoffman S;Markwald RR
骨膜素是不断增长的基质细胞蛋白家族的一员，其定义是其与细胞外环境成分以及细胞表面受体相互作用的能力。通过这些相互作用，骨膜素已被证明作为促纤维化分子在组织形态发生过程中发挥着至关重要的作用。注定要成为纤维结构的组织依赖于骨膜素及其结合伙伴之间的合作相互作用，而如果没有骨膜素，这些结构要么完全或部分无法成为成熟的纤维实体。在心脏内，正常组织成熟、重塑和功能以及对病理性心肌损伤的反应需要纤维化分化。在这篇综述中，总结了与骨膜素在心脏形态发生、重塑和病理学过程中的功能相关的方面。
Periostin is a member of a growing family of matricellular proteins, defined by their ability to interact with components of the extracellular milieu, and with receptors at the cell surface. Through these interactions, periostin has been shown to play a crucial role as a profibrogenic molecule during tissue morphogenesis. Tissues destined to become fibrous structures are dependent on cooperative interactions between periostin and its binding partners, whereas in its absence, these structures either totally or partially fail to become mature fibrous entities. Within the heart, fibrogenic differentiation is required for normal tissue maturation, remodeling and function, as well as in response to a pathological myocardial insult. In this review, aspects related to the function of periostin during cardiac morphogenesis, remodeling and pathology are summarized.
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DOI：
10.1083/jcb.200810094
发表时间：
2009-02-09
期刊：
The Journal of cell biology
影响因子：
--
作者：
Ausoni S;Sartore S
通讯作者：
Sartore S
影响因子：
37.8
作者：
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通讯作者：
WELLENS, HJJ
DOI：
10.1152/ajpheart.00514.2007
发表时间：
2007-09-01
影响因子：
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作者：
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通讯作者：
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Osf2/Cbfa1：成骨细胞分化的转录激活因子
影响因子：
64.5
作者：
Ducy, P;Zhang, R;Karsenty, G
通讯作者：
Karsenty, G
影响因子：
10.8
作者：
Haudek, Sandra B.;Gupta, Damon;Entman, Mark L.
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Entman, Mark L.