Removal of off-resonance xenon gas artifacts in pulmonary gas-transfer MRI.
Removal of off-resonance xenon gas artifacts in pulmonary gas-transfer MRI.
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DOI：
10.1002/mrm.28737
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发表时间：
2021-08
影响因子：
3.3
通讯作者：
Woods JC
中科院分区：
文献类型：
--
作者：
Willmering MM;Cleveland ZI;Walkup LL;Woods JC
超极化129Xe气体传输成像允许在单次呼吸中单独评估肺气体传输的不同组成部分-肺泡空气空间，肺间质/血浆（屏障）和红细胞（rbc）。然而，定量分析是具有挑战性的，因为溶解相129Xe图像经常被不完全选择性激励产生的非谐振气相信号污染。虽然以前的方法需要额外的气相去除数据，但我们报告了一种不需要/最小的序列修改/数据采集的方法，允许许多先前获得的图像进行追溯校正。129Xe成像在3.0T下通过交错3d径向采集假体和46名受试者的气相和溶解相（使用1点Dixon重建溶解相）进行。使用改进的气相图像从气传数据中去除气相污染（9.5±4.8%）。比较去除污染前后的信噪比和信号分布。此外，理论气体污染模拟在不同的磁场强度进行比较。由于频率偏移较大，与模拟的1.5T污染相比，3.0T时的气相污染更为弥漫性，主要位于肺外。幻影实验表明其去除效率为91%。在人类受试者中，尽管污染较低，但污染去除对溶解信号信噪比（+7.8%）、均值（- 1.4%）和标准差（- 2.3%）产生了显著变化。重复测量显示方差减小（溶解平均值：- 1.0%，标准差：- 8.4%）。非共振气相污染可以在没有/最小的序列修改的情况下健壮地去除。污染去除允许更准确的定量，降低射频严格性要求，并增加数据一致性，提供多中心试验所需的更高灵敏度。
Hyperpolarized 129Xe gas-transfer imaging allows different components of pulmonary gas transfer - alveolar air space, lung interstitium/blood plasma (barrier), and red blood cells (RBCs) - to be assessed separately in a single breath. However, quantitative analysis is challenging, because dissolved-phase 129Xe images are often contaminated by off-resonant gas-phase signal generated via imperfectly selective excitation. While previous methods required additional data for gas-phase removal we report a method requiring no/minimal sequence modifications/data acquisitions, allowing many previously acquired images to be corrected retroactively. 129Xe imaging was implemented at 3.0T via an interleaved 3D-radial acquisition of the gaseous and dissolved phases (using 1-point Dixon reconstruction for the dissolved-phase) in a phantom and 46 human subjects. Gas-phase contamination (9.5±4.8%) was removed from gas-transfer data using a modified gas-phase image. SNR and signal distributions were compared before and after contamination removal. Additionally, theoretical gaseous contaminations were simulated at different magnetic field strengths for comparison. Gas-phase contamination at 3.0T was more diffuse and located predominantly outside the lungs, relative to simulated 1.5T contamination, due to the larger frequency offset. Phantom experiments illustrated a 91% removal efficiency. In human subjects, contamination removal produced significant changes in dissolved signal SNR (+7.8%), mean (−1.4%), and standard deviation (−2.3%) despite low contamination. Repeat measurements showed reduced variance (dissolved mean: −1.0%, standard deviation: −8.4%). Off-resonance gas-phase contamination can be removed robustly with no/minimal sequence modifications. Contamination removal permits more accurate quantification, reduces rf stringency requirements, and increases data consistency, providing improved sensitivity needed for multi-center trials.
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影响因子：
4.4
作者：
Mugler, John P.;Altes, Talissa A.
通讯作者：
Altes, Talissa A.
影响因子：
4.8
作者：
He M;Driehuys B;Que LG;Huang YT
通讯作者：
Huang YT
超极化（129）XE用于研究小儿患者的轻度囊性纤维化肺疾病。
DOI：
10.1016/j.jcf.2016.07.008
发表时间：
2017-03
期刊：
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
影响因子：
--
作者：
Thomen RP;Walkup LL;Roach DJ;Cleveland ZI;Clancy JP;Woods JC
通讯作者：
Woods JC
影响因子：
3.3
作者：
Hahn, Andrew D.;Kammerman, Jeff;Fain, Sean B.
通讯作者：
Fain, Sean B.
影响因子：
3.3
作者：
Ebner, Lukas;Kammerman, Jeff;Driehuys, Bastiaan;Schiebler, Mark L.;Cadman, Robert V.;Fain, Sean B.
通讯作者：
Fain, Sean B.