Opposing effects of sodium intake on uric acid and blood pressure and their causal implication.
Opposing effects of sodium intake on uric acid and blood pressure and their causal implication.
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DOI：
10.1016/j.jash.2016.10.012
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Miller ER 3rd
中科院分区：
文献类型：
--
作者：
Juraschek SP;Choi HK;Tang O;Appel LJ;Miller ER 3rd
减少尿酸被认为可以降低血压，尽管证据并不一致。在dash -钠试验的辅助试验中，我们检查了钠诱导的血清尿酸（SUA）变化是否与血压变化相关。103名患有前期或1期高血压的成年人，被随机分配接受DASH饮食或对照饮食（典型的美国平均饮食），并按随机顺序分别饲喂3种钠水平（低、中、高）30天。体重保持不变。在基线和每个喂养期后测量SUA。参与者中55%是女性，75%是黑人。平均年龄52岁（SD, 10）岁，基线时平均SUA为5.0 (SD, 1.3) mg/dL。从低到高的钠摄入量增加会降低SUA (- 0.4 mg/dL, P < 0.001)，但会增加收缩压（4.3 mm Hg, P < 0.001）和舒张压（2.3 mm Hg, P < 0.001）。此外，SUA的变化与收缩压（P = 0.15）和舒张压（P = 0.63）的变化无关，与基线血压、基线SUA、随机饮食以及钠敏感性无关。虽然SUA和血压都受到钠（一种常见的环境因素）的影响，但它们的影响方向相反，彼此无关。这些发现不支持SUA和BP之间一致的因果关系。
Reducing uric acid is hypothesized to lower blood pressure, although evidence is inconsistent. In this ancillary of the DASH-Sodium trial, we examined whether sodium-induced changes in serum uric acid (SUA) were associated with changes in blood pressure. One hundred and three adults with pre- or stage 1 hypertension, were randomly assigned to receive either the DASH diet or a control diet (typical of the average American diet) and were fed each of 3 sodium levels (low, medium, and high) for 30 days in random order. Body weight was kept constant. SUA was measured at baseline and following each feeding period. Participants were 55% women and 75% black. Mean age was 52 (SD, 10) years, and mean SUA at baseline was 5.0 (SD, 1.3) mg/dL. Increasing sodium intake from low to high reduced SUA (−0.4 mg/dL; P < 0.001), but increased systolic (4.3 mm Hg; P < 0.001) and diastolic blood pressure (2.3 mm Hg; P < 0.001). Furthermore, changes in SUA were independent of changes in systolic (P = 0.15) and diastolic (P = 0.63) blood pressure, regardless of baseline blood pressure, baseline SUA, and randomized diet, as well as sodium sensitivity. While both SUA and blood pressure were influenced by sodium, a common environmental factor, their effects were in opposite directions and were unrelated to each other. These findings do not support a consistent causal relationship between SUA and BP.
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影响因子：
4.7
作者：
Nerbass, F. B.;Pecoits-Filho, R.;Taal, M. W.
通讯作者：
Taal, M. W.
影响因子：
120.7
作者：
Fang, J;Alderman, MH
通讯作者：
Alderman, MH
影响因子：
120.7
作者：
He, JA;Ogden, LG;Whelton, PK
通讯作者：
Whelton, PK
绝经和激素替代疗法对高尿酸血症与死亡率关联的影响。
影响因子：
5.3
作者：
Ioannou GN;Boyko EJ
通讯作者：
Boyko EJ
影响因子：
37.8
作者：
Forman JP;Scheven L;de Jong PE;Bakker SJ;Curhan GC;Gansevoort RT
通讯作者：
Gansevoort RT