Association of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) with uric acid among adults with elevated community exposure to PFOA.
Association of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) with uric acid among adults with elevated community exposure to PFOA.
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DOI：
10.1289/ehp.0900940
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发表时间：
2010-02
影响因子：
10.4
通讯作者：
Ducatman A
中科院分区：
文献类型：
--
作者：
Steenland K;Tinker S;Shankar A;Ducatman A
全氟辛酸 (PFOA) 和全氟辛烷磺酸 (PFOS) 是自然界中不存在的化合物，自二战以来已广泛使用，并在大多数环境中无限期存在。美国的 PFOA 血清浓度中位数为 4 ng/mL，PFOS 血清浓度中位数为 21 ng/mL。两项针对化学工人的研究表明，PFOA 与尿酸升高有关。尿酸是高血压和其他心血管疾病的危险因素。我们对俄亥俄州和西弗吉尼亚州的 54,951 名成年社区居民进行了 PFOA、PFOS 和尿酸的横断面研究，这些居民在六个受化工厂 PFOA 污染的水域中生活或工作。通过线性回归和逻辑回归进行分析，并针对混杂因素进行调整。 PFOA 和 PFOS 均与尿酸显着相关。尿酸增加 0.2–0.3 mg/dL 与 PFOA 或 PFOS 从最低十分位数到最高十分位数的增加相关。随着 PFOA 的增加，高尿酸血症风险略有增加； PFOA 五分位数的比值比分别为 1.00、1.33 [95% 置信区间 (CI)，1.24–1.43]、1.35 (95% CI，1.26–1.45)、1.47 (95% CI，1.37–1.58) 和 1.47 (95% CI，1.37–1.58；检验对于趋势，p < 0.0001）。我们看到全氟辛烷磺酸的趋势不那么陡峭。模型中包含两种相关的碳氟化合物表明 PFOA 是比 PFOS 更重要的预测因子。较高的 PFOA 血清水平与较高的高尿酸血症患病率相关，但横截面数据的局限性和非因果机制的可能性阻碍了有关因果关系的结论。
Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are compounds that do not occur in nature, have been widely used since World War II, and persist indefinitely in most environments. Median serum levels in the United States are 4 ng/mL for PFOA and 21 ng/mL for PFOS. PFOA has been associated with elevated uric acid in two studies of chemical workers. Uric acid is a risk factor for hypertension and possibly other cardiovascular outcomes. We conducted a cross-sectional study of PFOA and PFOS and uric acid among 54,951 adult community residents in Ohio and West Virginia, who lived or worked in six water districts contaminated with PFOA from a chemical plant. Analyses were conducted by linear and logistic regression, adjusted for confounders. Both PFOA and PFOS were significantly associated with uric acid. An increase of 0.2–0.3 mg/dL uric acid was associated with an increase from the lowest to highest decile of either PFOA or PFOS. Hyperuricemia risk increased modestly with increasing PFOA; the odds ratios by quintile of PFOA were 1.00, 1.33 [95% confidence interval (CI), 1.24–1.43], 1.35 (95% CI, 1.26–1.45), 1.47 (95% CI, 1.37–1.58), and 1.47 (95% CI, 1.37–1.58; test for trend, p < 0.0001). We saw a less steep trend for PFOS. Inclusion of both correlated fluorocarbons in the model indicated PFOA was a more important predictor than was PFOS. Higher serum levels of PFOA were associated with a higher prevalence of hyperuricemia, but the limitations of cross-sectional data and the possibility of noncausal mechanisms prohibit conclusions regarding causality.
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影响因子：
4.5
作者：
Hayden MR;Tyagi SC
通讯作者：
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影响因子：
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作者：
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DOI：
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发表时间：
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