Oestradiol modulation of cognition in adult female marmosets (Callithrix jacchus).
Oestradiol modulation of cognition in adult female marmosets (Callithrix jacchus).
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DOI：
10.1111/jne.12147
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发表时间：
2014-05
影响因子：
3.2
通讯作者：
Ferris CM
中科院分区：
文献类型：
--
作者：
Lacreuse A;Chang J;Metevier CM;LaClair M;Meyer JS;Ferris CM
普通狨猴（Callithrix jacchus）作为人类衰老的模型，比传统的啮齿动物和猕猴物种有许多优势，对研究性类固醇对认知和大脑衰老的影响可能非常有价值。我们提出了第一项研究，检查雌激素对雌性狨猴认知功能的影响。成年猴子（3-5岁）在术前接受一系列认知任务的特定学习标准训练（物体识别，延迟反应增加和绕行不透明盒子），并在卵巢切除术和同时植入17β-雌二醇（E2, n=6）或空白（n=6）硅胶胶囊后测试这些任务的不同版本（物体逆转，随机延迟反应延迟和绕行透明盒子）。在完成这些测试后，还进行了延迟15秒的延迟匹配到位置任务的获取。e2治疗的猴子在第二次逆转时明显受损，从逆转1到逆转3显示出持续反应的增加。它们在延迟反应任务中的表现也往往比对照组的猴子差。e2组相对于对照组在DMP上表现得更好，但组间差异无统计学意义。没有检测到治疗对绕道到达或附属行为的影响。总的来说，研究结果表明E2会影响前额叶介导任务的表现。E2可能会改善依赖海马体的任务的习得，这一建议需要进一步的验证。这些结果在多巴胺能和血清素能信号的背景下进行了讨论。我们得出结论，狨猴是一个有用的新的灵长类动物模型来研究雌激素对认知功能的影响。
The common marmoset (Callithrix jacchus) provides many advantages over traditional rodent and macaque species as a model for human aging and may be very valuable to study the effects of sex steroids on cognitive and brain aging. We present the first study examining the effects of oestrogens on cognitive function in female marmosets. Adult monkeys (3-5 years of age) were trained to a specific learning criterion on a battery of cognitive tasks preoperatively (object discrimination, delayed response with increasing delays and detour reaching with opaque box) and tested on different versions of these tasks (object reversals, delayed response with randomised delays and detour reaching with clear box) following ovariectomy and simultaneous implantation with 17β-oestradiol (E2, n=6) or blank (n=6) Silastic capsules. Acquisition of a delayed matching-to-position task with a 1s delay was also administered following completion of these tests. E2-treated monkeys were significantly impaired on the second Reversal and showed an increase in perseverative responding from Reversals 1 to 3. Their performance also tended to be worse than that of control monkeys on the Delayed Response task. Performance acquisition on the DMP tended to be better in E2-treated relative to control monkeys, but the group difference did not reach statistical significance. No effect of treatment was detected for Detour Reaching or affiliative behaviours. Overall, the findings indicate that E2 compromises performance on prefrontally-mediated tasks. The suggestion that E2 may improve acquisition on tasks dependent on the hippocampus will require further validation. These results are discussed in the context of dopaminergic and serotonergic signaling. We conclude that the marmoset is a useful new primate model to examine the effects of oestrogens on cognitive function.
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影响因子：
1.9
作者：
Collins, P;Wilkinson, LS;Roberts, AC
通讯作者：
Roberts, AC
影响因子：
3.7
作者：
Epperson, C. Neill;Amin, Zenab;Ruparel, Kosha;Gur, Ruben;Loughead, James
通讯作者：
Loughead, James
DOI：
10.1523/jneurosci.1521-08.2008
发表时间：
2008-10-22
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Clarke HF;Robbins TW;Roberts AC
通讯作者：
Roberts AC
影响因子：
12.7
作者：
Geula, C;Nagykery, N;Wu, CK
通讯作者：
Wu, CK
影响因子：
3.5
作者：
Duff, SJ;Hampson, E
通讯作者：
Hampson, E