Fascin-1 is a novel biomarker of aggressiveness in some carcinomas.
Fascin-1 is a novel biomarker of aggressiveness in some carcinomas.
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DOI：
10.1186/1741-7015-11-53
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发表时间：
2013-02-26
期刊：
影响因子：
9.3
通讯作者：
Diamandis EP
中科院分区：
文献类型：
--
作者：
Kulasingam V;Diamandis EP
近年来，在了解、预防和管理恶性疾病方面取得了巨大进展，但癌症仍然是全球死亡率和发病率的主要原因。目前防治这一疾病的办法包括预防、早期发现和各种治疗方式。然而，即使实施了新的治疗选择和预防措施，目前大多数癌症都是在晚期被诊断出来的，此时的治疗方法效果最差。在最近发表在BMC Medicine上的一项研究中，Tan等人进行了系统性综述和荟萃分析，表明fascin-1（一种肌动蛋白捆绑蛋白）与各种癌症类型的死亡率和转移风险增加有关。尽管该研究检查了fascin-1与五种主要癌症类型的死亡率，疾病进展时间，淋巴结转移和远处转移的相关性，但这些发现的临床意义仍然不清楚，许多未回答的问题仍然存在。请参阅相关的研究文章在这里http://www.biomedcentral.com/1741-7015/11/52
Tremendous progress has been made in recent years towards the understanding, prevention and management of malignant disease, yet cancer remains a leading cause of global mortality and morbidity. Current approaches towards combating this disease include prevention, early detection and various treatment modalities. However, even with implementation of novel therapeutic options and preventative measures, most cancers are currently diagnosed at late stages, when treatment therapies are least effective. In a recent study published in BMC Medicine, Tan et al. performed a systematic review and meta-analysis to show that fascin-1, an actin-bundling protein, is associated with increased risk of mortality and metastasis in various cancer types. Although the study examined the association of fascin-1 with mortality, time-to-disease progression, lymph node metastasis and distant metastasis in five major cancer types, the clinical implications of these findings are still unclear and many unanswered questions remain. Please see related research article here http://www.biomedcentral.com/1741-7015/11/52
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影响因子：
3.8
作者：
Hashimoto Y;Skacel M;Lavery IC;Mukherjee AL;Casey G;Adams JC
通讯作者：
Adams JC
影响因子：
254.7
作者：
Siegel, Rebecca;Naishadham, Deepa;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin
影响因子：
9.3
作者：
Tan VY;Lewis SJ;Adams JC;Martin RM
通讯作者：
Martin RM
影响因子：
9.3
作者：
Diamandis EP
通讯作者：
Diamandis EP