Complement's favourite organelle-Mitochondria?
Complement's favourite organelle-Mitochondria?
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DOI：
10.1111/bph.15238
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发表时间：
2021-07
影响因子：
7.3
通讯作者：
Kemper C
中科院分区：
文献类型：
--
作者：
Rahman J;Singh P;Merle NS;Niyonzima N;Kemper C
补体系统，众所周知其在先天免疫中的核心作用，目前正在成为一个意想不到的，细胞自主的，正常细胞生理学的协调者。具体地说，细胞内活性补体系统-补体体-控制免疫细胞稳态和效应子功能期间正常细胞代谢的关键途径。到目前为止，我们对细胞内补体成分在细胞内和细胞间的确切结构和定位知之甚少。然而，一个常见的方案是，它们与其他细胞内免疫传感器（如炎性小体）发生串扰，并且它们影响关键亚细胞区室的活性。在细胞间室中，线粒体似乎已经与补体和细胞外活性补体建立了特别早期和强烈的关系，鉴于补体对代谢的强烈影响，这并不奇怪。在这篇综述中，我们将总结目前的知识，密切的线粒体-线粒体的关系，并讨论围绕这一新的研究领域的关键问题。本文是关于健康和疾病中补体系统的规范和非规范功能的主题问题的一部分。要查看本节中的其他文章，请访问http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.14/issuetoc
The complement system, well known for its central role in innate immunity, is currently emerging as an unexpected, cell‐autonomous, orchestrator of normal cell physiology. Specifically, an intracellularly active complement system—the complosome—controls key pathways of normal cell metabolism during immune cell homeostasis and effector function. So far, we know little about the exact structure and localization of intracellular complement components within and among cells. A common scheme, however, is that they operate in crosstalk with other intracellular immune sensors, such as inflammasomes, and that they impact on the activity of key subcellular compartments. Among cell compartments, mitochondria appear to have built a particularly early and strong relationship with the complosome and extracellularly active complement—not surprising in view of the strong impact of the complosome on metabolism. In this review, we will hence summarize the current knowledge about the close complosome–mitochondria relationship and also discuss key questions surrounding this novel research area. This article is part of a themed issue on Canonical and non‐canonical functions of the complement system in health and disease. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.14/issuetoc
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影响因子：
16.6
作者：
Arbore G;West EE;Rahman J;Le Friec G;Niyonzima N;Pirooznia M;Tunc I;Pavlidis P;Powell N;Li Y;Liu P;Servais A;Couzi L;Fremeaux-Bacchi V;Placais L;Ferraro A;Walsh PR;Kavanagh D;Afzali B;Lavender P;Lachmann HJ;Kemper C
通讯作者：
Kemper C
T 辅助细胞 1 免疫需要 CD4⁺ T 细胞中补体驱动的 NLRP3 炎性体活性。
DOI：
10.1126/science.aad1210
发表时间：
2016-06-17
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Arbore G;West EE;Spolski R;Robertson AAB;Klos A;Rheinheimer C;Dutow P;Woodruff TM;Yu ZX;O'Neill LA;Coll RC;Sher A;Leonard WJ;Köhl J;Monk P;Cooper MA;Arno M;Afzali B;Lachmann HJ;Cope AP;Mayer-Barber KD;Kemper C
通讯作者：
Kemper C
影响因子：
7.3
作者：
Angajala A;Lim S;Phillips JB;Kim JH;Yates C;You Z;Tan M
通讯作者：
Tan M
影响因子：
7.3
作者：
Alexander, Stephen P. H.;Kelly, Eamonn;Davies, Jamie A.
通讯作者：
Davies, Jamie A.
影响因子：
5.4
作者：
Dinarello, Charles A.
通讯作者：
Dinarello, Charles A.