Ionic shift in cerebral ischemia.

Ionic shift in cerebral ischemia.
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脑缺血中的离子转移。

DOI:
10.1016/0024-3205(82)90473-8
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发表时间:
1982
期刊:
影响因子:
6.1
通讯作者:
McCall,JT
McCall,JT
中科院分区:
医学2区
文献类型:
--
作者:
Yanagihara,T;McCall,JT

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测定沙土鼠脑缺血后电解质和水含量。缺血30分钟后,Na+和水增加,K+减少。然而,这些异常在3小时内消失。当缺血时间延长至3小时时,再次出现缺血30分钟后观察到的异常,但在血流重建后立即发生更显著的变化。除Na+明显升高、K+明显降低外,Ca ~(2+)在再灌流15 min后明显升高,再灌流3 h后逐渐升高。Ca ~(2+)的持续升高与脑缺血的不可逆性有关。
Electrolyte and water contents were measured in gerbil brain after unilateral cerebral ischemia. Increase of Na+and water, and decrease of K+occurred after an ischemic period of 30 minutes. However, these abnormalities disappeared within 3 hours. When the ischemic period was extended to 3 hours, the abnormalities observed after ischemia for 30 minutes were again encountered, but more significant alterations occurred immediately after re-establishment of blood flow. In addition to more pronounced increase of Na+and decrease of K+, Ca2+became significantly elevated after recirculation for 15 minutes and progressively increased during recirculation for 3 hours. The steady rise of Ca2+appears to be related to the irreversibility of cerebral ischemia.
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DOI: --
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