Prevalence, pathophysiology, and treatment of rhegmatogenous retinal detachment in treated cytomegalovirus retinitis.
Prevalence, pathophysiology, and treatment of rhegmatogenous retinal detachment in treated cytomegalovirus retinitis.
复制标题
巨细胞病毒性视网膜炎治疗后孔源性视网膜脱离的患病率、病理生理学和治疗。
DOI：
10.1016/s0002-9394(14)74276-x
复制
发表时间：
1987
影响因子：
4.2
通讯作者：
Narsing A. Rao
中科院分区：
文献类型：
--
作者：
W. R. Freeman;D. Henderly;W. Lee Wan;Dennis M. Causey;Melvin D. Trousdale;Ronald L. Green;Narsing A. Rao
17例获得性免疫缺陷综合征合并巨细胞病毒性视网膜炎患者接受抗病毒药物更昔洛韦（9-[1，3-二羟基-2-丙氧基甲基]-鸟嘌呤，DHPG）治疗。5例患者的8只眼在开始治疗后发生了孔源性视网膜脱离。周边、愈合、萎缩性视网膜区域的多处断裂导致了视网膜脱离。所有7只接受手术的眼睛都有广泛的视网膜脱离，用玻璃体切除术和硅油重新连接。2例合并严重增生性玻璃体视网膜病变，需行视网膜切开及视网膜钉扎术。在一名患者的另一只眼睛中，激光治疗被用于治疗已愈合的视网膜炎的周边补丁。对五只眼睛进行了视网膜内活检和培养;尽管同时进行了临床有效的抗病毒治疗，但在两例病例中仍发现了持续存在巨细胞病毒的证据。
Seventeen patients with the acquired immune deficiency syndrome and cytomegalovirus retinitis were treated with the antiviral drug ganciclovir (9-[1,3-dihydroxy-2-propoxymethyl]-guanine, DHPG). Eight eyes of five patients developed rhegmatogenous retinal detachment after initiation of treatment. Multiple breaks in areas of peripheral, healed, atrophic retina accounted for the detachments. All seven eyes that underwent surgery had extensive retinal detachments that were reattached with vitrectomy and silicone oil. Retinotomy and retinal tacks were necessary in two cases that were complicated by severe proliferative vitreoretinopathy. In the fellow eye of one patient, laser treatment was used prophylactically to wall off a peripheral patch of healed retinitis. Endoretinal biopsies and culture were taken in five eyes; evidence of persistent cytomegalovirus was seen in two cases despite concurrent and clinically effective antiviral therapy.
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影响因子：
13.7
作者：
Pepose,JS;Holland,GN;Nestor,MS;Cochran,AJ;Foos,RY
通讯作者：
Foos,RY
9-[2-羟基-1-(羟甲基)乙氧基甲基]鸟嘌呤治疗巨细胞病毒肺炎的活性。
影响因子：
39.2
作者：
Shepp,DH;Dandliker,PS;deMiranda,P;Burnette,TC;Cederberg,DM;Kirk,LE;Meyers,JD
通讯作者：
Meyers,JD
影响因子：
--
作者：
MILLER, B;MILLER, H;RYAN, SJ
通讯作者：
RYAN, SJ
巨细胞病毒性视网膜炎：获得性免疫缺陷综合征（艾滋病）的一种表现。
DOI：
10.1136/bjo.67.6.372
发表时间：
1983
期刊：
The British journal of ophthalmology
影响因子：
--
作者：
Friedman,AH;Orellana,J;Freeman,WR;Luntz,MH;Starr,MB;Tapper,ML;Spigland,I;Roterdam,H;MesaTejada,R;Braunhut,S;Mildvan,D;Mathur,U
通讯作者：
Mathur,U