Peri-implantation cytokine profile differs between singleton and twin IVF pregnancies.
Peri-implantation cytokine profile differs between singleton and twin IVF pregnancies.
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单胎和双胎IVF妊娠的围植入期细胞因子谱不同。
DOI：
10.1111/aji.13348
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Pal L
中科院分区：
文献类型：
--
作者：
Simpson S;Kaislasuo J;Peng G;Aldo P;Paidas M;Guller S;Mor G;Pal L
双胎妊娠和单胎妊娠在着床期母体细胞因子的产生是否不同尚不清楚。双胞胎母体血清细胞因子浓度的差异意味着对入侵胚胎的剂量反应，而不是一般的免疫反应。在一个学术生育中心接受体外受精和胚胎移植（IVF-ET）的18-45岁女性的前瞻性纵向队列在ET后9天开始常规收集系列血清样本，然后大约每48小时收集一次。使用Simplepletion免疫分析平台，对这些样本的冻存等分试样进行白细胞介素-10（IL-10）、肿瘤坏死因子-α（TNF-α）和C-X-C基序趋化因子配体10（CXCL 10）分析。妊娠随访至分娩。比较单胎和双胎妊娠IVF-ET后9 ~ 15 d血清IL-10、CXCL 10和TNF-α水平的变化。与单胎妊娠相比，双-双胎妊娠早期着床的孕妇血清CXCL 10水平显著降低（第9-11天，P = 0.02）。在所有研究时间点，血清TNF-α和IL-10水平相当（P > 0.05）。与单胎妊娠相比，双胞胎最早着床阶段的母体血清CXCL 10水平显着较低。考虑到CXCL 10已知的抗血管生成作用，我们假设双胎胎盘中较低的CXCL 10水平允许一个有利于在双胎中建立双胎盘所需的更大血管化的环境。
It is unknown whether maternal cytokine production differs between twin and singleton gestations in the implantation phase. A difference in maternal serum cytokine concentrations in twins would imply a dose-response to the invading embryos, as opposed to a general immune reaction. A prospective longitudinal cohort of women aged 18–45 at an academic fertility center undergoing in vitro fertilization and embryo transfer (IVF-ET) underwent routine collection of serial serum samples starting 9 days after ET and then approximately every 48 hours thereafter. Cryopreserved aliquots of these samples were assayed for interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-α), and C-X-C motif chemokine ligand 10 (CXCL10) using the SimplePlex immunoassay platform. Pregnancies were followed until delivery. Serial measures of serum concentrations of IL-10, CXCL10, and TNF-α in singleton or di-di twin pregnancies from 9 to 15 days after IVF-ET were compared. Maternal serum levels of CXCL10 are significantly lower in women with di-di twin pregnancies in early implantation compared to those with singleton gestation (day 9–11, P = .02). Serum levels of TNF-α and IL-10 were comparable at all studied time points (P > .05). Maternal serum levels of CXCL10 are significantly lower in the earliest implantation phase in di-di twins compared to singleton conceptions. Given the known anti-angiogenic role of CXCL10, we hypothesize that lower CXCL10 levels in twin implantations allow an environment that is conducive for the greater vascularization required for the establishment of dual placentation in di-di twins.
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影响因子：
5.2
作者：
Mor G;Cardenas I;Abrahams V;Guller S
通讯作者：
Guller S
影响因子：
13
作者：
Neville, Lewis F.;Mathiak, Guenther;Bagasra, Omar
通讯作者：
Bagasra, Omar
影响因子：
6.7
作者：
Boomsma, Carolien M.;Kavelaars, Annemieke;Macklon, Nick S.
通讯作者：
Macklon, Nick S.
影响因子：
4.6
作者：
Silasi, Michelle;You, Yuan;Mor, Gil
通讯作者：
Mor, Gil
DOI：
10.1111/aji.12512
发表时间：
2016-06
期刊：
American journal of reproductive immunology (New York, N.Y. : 1989)
影响因子：
--
作者：
Aldo P;Marusov G;Svancara D;David J;Mor G
通讯作者：
Mor G