Reversible inactivation of the basolateral amygdala, but not the dorsolateral caudate putamen, attenuates consolidation of cocaine-cue associative learning in a reinstatement model of drug-seeking.
Reversible inactivation of the basolateral amygdala, but not the dorsolateral caudate putamen, attenuates consolidation of cocaine-cue associative learning in a reinstatement model of drug-seeking.
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DOI：
10.1111/j.1460-9568.2010.07394.x
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发表时间：
2010-09
期刊：
影响因子：
--
通讯作者：
See RE
中科院分区：
文献类型：
--
作者：
Gabriele A;See RE
先前的研究表明，基底外侧杏仁核（BLA）介导刺激-奖励学习，包括药物-线索关联，而背外侧尾壳核（dlCPu）主要介导刺激-反应（习惯）学习。最近的证据表明，dlCPu可能是关键的可卡因寻求延长自我管理后，但它仍然是未知的dlCPu是否在早期形成的药物线索协会的作用。目前的研究使用巴甫洛夫学习模型来比较BLA和dlCPu在巩固可卡因线索关联中的作用，这些关联在线索诱导的恢复过程中维持可卡因寻求。雄性Sprague-Dawley大鼠在无提示的情况下自我给予可卡因（0.2 mg/50 µl输注，IV）6天（2小时/天）。在单次1小时经典条件反射（CC）会话（其中被动可卡因输注与光+音调提示配对）之后，动物立即接受GABA受体激动剂巴氯芬+蝇蕈醇（B/M，1.0/0.1 mM）或载体双侧输注到BLA或dlCPu中。在额外的可卡因自我给药（5天）和随后的消退（无可卡因或线索，7天）后，评估了先前可卡因配对线索恢复可卡因寻求的能力。失活的BLA，但不是dlCPu，立即CC会议后受损的可卡因-线索协会的巩固减少线索诱导的恢复。这些结果扩展了先前的研究结果，即BLA介导了在随后的恢复过程中推动可卡因寻求的学习关联的巩固，并表明dlCPu在最初的刺激-药物联想学习过程中不起作用。
Previous research has shown that the basolateral amygdala (BLA) mediates stimulus-reward learning, including drug-cue associations, while the dorsolateral caudate-putamen (dlCPu) primarily mediates stimulus-response (habit) learning. Recent evidence has indicated that the dlCPu may be critical in cocaine-seeking following extended self-administration, but it remains unknown whether the dlCPu plays a role in early formation of drug-cue associations. The current study used a model of Pavlovian learning to compare the roles of the BLA and dlCPu in the consolidation of cocaine-cue associations that maintain cocaine-seeking during cue-induced reinstatement. Male, Sprague-Dawley rats self-administered cocaine (0.2 mg/50 µl infusion, IV) in the absence of cues for 6 days (2-h/day). Immediately following a single 1-h classical conditioning (CC) session in which passive cocaine infusions were paired with a light+tone cue, animals received bilateral infusions of the GABA receptor agonists, baclofen+muscimol (B/M, 1.0/0.1 mM), or vehicle into the BLA or dlCPu. Following additional cocaine self-administration (5 days) and subsequent extinction (no cocaine or cues, 7 days), the ability of the previously cocaine-paired cues to reinstate cocaine-seeking was assessed. Inactivation of the BLA, but not the dlCPu, immediately following the CC session impaired the consolidation of cocaine-cue associations as seen by decreased cue-induced reinstatement. These results extend previous findings that the BLA mediates the consolidation of learned associations that drive cocaine-seeking during subsequent reinstatement and indicate that the dlCPu does not play a role during initial stimulus-drug associative learning.
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影响因子：
3.3
作者：
EVERITT, BJ;MORRIS, KA;ROBBINS, TW
通讯作者：
ROBBINS, TW
影响因子：
2.7
作者：
Feltenstein, Matthew W.;See, Ronald E.
通讯作者：
See, Ronald E.
影响因子：
3.4
作者：
Kantak, KM;Black, Y;Eichenbaum, HB
通讯作者：
Eichenbaum, HB
影响因子：
5.3
作者：
Kruzich, PJ;See, RE
通讯作者：
See, RE
影响因子：
1.9
作者：
MCDONALD, RJ;WHITE, NM
通讯作者：
WHITE, NM