Epidemiology and Seasonality of Respiratory Viruses Detected from Children with Respiratory Tract Infections in Wuxi, East China.
Epidemiology and Seasonality of Respiratory Viruses Detected from Children with Respiratory Tract Infections in Wuxi, East China.
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DOI：
10.12659/msm.908483
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发表时间：
2018-03-30
期刊：
影响因子：
--
通讯作者：
Feng X
中科院分区：
文献类型：
--
作者：
Ge X;Guo Y;Chen J;Hu R;Feng X
呼吸道感染是发展中国家儿童死亡和发病的主要原因，并导致住院治疗。然而，很少有人知道的流行病学和呼吸道病毒的季节性在中国东部无锡的儿科人群。我们纳入了2010年1月至2016年12月期间出现RTI体征和症状的所有14岁及以下患者。在此期间，共有2160名在无锡市第二人民医院接受治疗的儿童参与了我们的研究。记录临床和社会人口学数据以描述频率和季节性。通过多重实时PCR检测呼吸道标本，以进行病毒鉴定。超过30% 760份标本中有35.19%的标本存在病毒感染，包括呼吸道合胞病毒（368份样本），甲型流感病毒（114份样本），流感病毒B（115份样本），副流感病毒I型病毒感染者中，副流感病毒Ⅱ型39例，副流感病毒Ⅲ型13例，腺病毒82例，其中12月龄以下儿童占48.99%。全年都检测到病毒，冬季为高峰。我们的研究发现，RSV是我们地区冬季呼吸道感染的最重要原因。我们的数据提供了对病毒流行病学和季节性的全面了解，这可能有助于减少抗生素的使用，并实施有效的预防，控制和治疗RTI的方法，特别是在其高峰期。
Respiratory tract infections (RTIs) are the major causes of mortality and morbidity in children and lead to hospitalization in developing countries. However, little is known about the epidemiology and seasonality of respiratory viruses in the pediatric population in Wuxi, East China. We included all patients 14 years of age and below who presented with signs and symptoms of RTIs between January 2010 and December 2016. During this period, a total of 2160 children treated in Wuxi No. 2 People’s Hospital were involved in our study. The clinical and sociodemographic data were recorded to describe the frequency and seasonality. Respiratory specimens were tested by multiplex real-time PCR assays for virus identification. More than 30% (35.19%, 760 samples) of the specimens showed evidence of infection with viruses, including respiratory syncytial virus (368 samples), influenza virus A (114 samples), influenza virus B (115 samples), parainfluenza virus I (29 samples), parainfluenza virus II (39 samples), parainfluenza virus III (13 samples), and adenovirus (82 samples); 48.99% of the children infected with viruses were under 12 months of age. Viruses were detected throughout all the year, with a peak in winter. Our study found that RSV is the most important cause of RTIs in our region during winter. Our data provide a comprehensive understanding of the epidemiology and seasonality of virus, which may help to reduce the use of antibiotics and implement an effective approach for prevention, control, and treatment of RTIs, especially during its peak season.
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DOI：
10.1016/j.jcv.2015.01.006
发表时间：
2015-03
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
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作者：
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