Neural circuitry underlying the regulation of conditioned fear and its relation to extinction.
Neural circuitry underlying the regulation of conditioned fear and its relation to extinction.
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DOI：
10.1016/j.neuron.2008.06.029
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发表时间：
2008-09-11
期刊：
影响因子：
16.2
通讯作者：
Phelps EA
中科院分区：
文献类型：
--
作者：
Delgado MR;Nearing KI;Ledoux JE;Phelps EA
最近，将基础研究转化为临床疾病治疗的努力，使人们对探索减少恐惧的机制越来越感兴趣。这项研究强调了两种方法：条件性恐惧的消退，跨物种进行研究;以及人类特有的认知情绪调节。在这里，我们试图研究这两种减少恐惧的范式背后的神经机制的相似性和差异。使用情绪调节策略，我们研究了神经机制，调节条件性恐惧，使用功能磁共振成像和比较所产生的激活模式与经典灭绝过程中观察到的。我们的研究结果表明，参与认知情绪调节策略的外侧PFC区域可能会影响杏仁核，通过类似的VMPFC连接减少恐惧，这种连接被认为在灭绝过程中抑制杏仁核。这些发现进一步表明，人类可能已经发展出复杂的认知能力，可以帮助调节情绪反应，同时利用遗传学上共享的灭绝机制。
Recent efforts to translate basic research to the treatment of clinical disorders have led to a growing interest in exploring mechanisms for diminishing fear. This research has emphasized two approaches: extinction of conditioned fear, examined across species; and cognitive emotion regulation, unique to humans. Here, we sought to examine the similarities and differences in the neural mechanisms underlying these two paradigms for diminishing fear. Using an emotion regulation strategy, we examine the neural mechanisms of regulating conditioned fear using fMRI and compare the resulting activation pattern with that observed during classic extinction. Our results suggest that the lateral PFC regions engaged by cognitive emotion regulation strategies may influence the amygdala, diminishing fear through similar vmPFC connections that are thought to inhibit the amygdala during extinction. These findings further suggest that humans may have developed complex cognition that can aid in regulating emotional responses while utilizing phylogenetically shared mechanisms of extinction.
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影响因子：
4.1
作者：
Groenewegen, HJ;Wright, CI;Uylings, HBM
通讯作者：
Uylings, HBM
影响因子：
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LaBar, KS;Gatenby, JC;Phelps, EA
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作者：
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