Genomic analysis of a parasite invasion: Colonization of the Americas by the blood fluke Schistosoma mansoni.
Genomic analysis of a parasite invasion: Colonization of the Americas by the blood fluke Schistosoma mansoni.
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DOI：
10.1111/mec.16395
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发表时间：
2022-04
影响因子：
4.9
通讯作者：
Anderson, Timothy J. C.
中科院分区：
文献类型：
--
作者：
Platt, Roy N., II;Le Clec'h, Winka;Chevalier, Frederic D.;McDew-White, Marina;LoVerde, Philip T.;de Assis, Rafael Ramiro;Oliveira, Guilherme;Kinung'hi, Safari;Djirmay, Amadou Garba;Steinauer, Michelle L.;Gouvras, Anouk;Rabone, Muriel;Allan, Fiona;Webster, Bonnie L.;Webster, Joanne P.;Emery, Aidan M.;Rollinson, David;Anderson, Timothy J. C.
曼氏血吸虫是一种感染人类的蜗牛传播的血吸虫，在跨大西洋奴隶贸易期间从非洲传入美洲。由于这种寄生虫对蜗牛中间宿主表现出很强的特异性，我们预计这种寄生虫对南美双脐螺的适应性。蜗牛会导致种群瓶颈和强烈的选择信号。我们在143个S中获得了475，081个单核苷酸变异。mansoni人从美洲（巴西、瓜德罗普和波多黎各）和非洲（喀麦隆、尼日尔、塞内加尔、坦桑尼亚和乌干达）收集数据，并利用这些数据提出以下问题：（i）殖民化期间是否存在人口瓶颈？(ii)我们能识别出与殖民化相关的选择特征吗？(iii)寄生虫的来源人群是什么？我们发现，从东非到西非的寄生虫多样性减少了2.4至2.9倍，连锁不平衡（LD）的衰减要慢得多。然而，我们在西非和巴西观察到了类似的核多样性和LD，这表明殖民化没有强大的瓶颈和有限的障碍。我们确定了五个基因组区域显示选择在美洲，相比之下，在西非和东非，我们推测这可能反映了适应殖民过程中。最后，我们推断来自贝宁和安哥拉之间的中非地区的未取样种群，加上来自尼日尔的贡献，可能是巴西S. mansoni没有瓶颈表明这是一个偶然入侵的罕见案例，S。曼氏寄生虫预先适应了美洲，并且能够相对容易地建立。
Schistosoma mansoni, a snail‐borne, blood fluke that infects humans, was introduced into the Americas from Africa during the Trans‐Atlantic slave trade. As this parasite shows strong specificity to the snail intermediate host, we expected that adaptation to South American Biomphalaria spp. snails would result in population bottlenecks and strong signatures of selection. We scored 475,081 single nucleotide variants in 143 S. mansoni from the Americas (Brazil, Guadeloupe and Puerto Rico) and Africa (Cameroon, Niger, Senegal, Tanzania, and Uganda), and used these data to ask: (i) Was there a population bottleneck during colonization? (ii) Can we identify signatures of selection associated with colonization? (iii) What were the source populations for colonizing parasites? We found a 2.4‐ to 2.9‐fold reduction in diversity and much slower decay in linkage disequilibrium (LD) in parasites from East to West Africa. However, we observed similar nuclear diversity and LD in West Africa and Brazil, suggesting no strong bottlenecks and limited barriers to colonization. We identified five genome regions showing selection in the Americas, compared with three in West Africa and none in East Africa, which we speculate may reflect adaptation during colonization. Finally, we infer that unsampled populations from central African regions between Benin and Angola, with contributions from Niger, are probably the major source(s) for Brazilian S. mansoni. The absence of a bottleneck suggests that this is a rare case of a serendipitous invasion, where S. mansoni parasites were pre‐adapted to the Americas and able to establish with relative ease.
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影响因子：
9.6
作者：
Anderson TJC;LoVerde PT;Le Clec'h W;Chevalier FD
通讯作者：
Chevalier FD
DOI：
10.1098/rspb.2000.1367
发表时间：
2001-02-07
影响因子：
4.7
作者：
Davies, CM;Webster, JP;Woolhouse, MEJ
通讯作者：
Woolhouse, MEJ
影响因子：
9.6
作者：
Anderson TJC;Enabulele EE
通讯作者：
Enabulele EE
DOI：
10.1073/pnas.2110711118
发表时间：
2021-10-12
影响因子：
11.1
作者：
Borlase A;Rudge JW;Léger E;Diouf ND;Fall CB;Diop SD;Catalano S;Sène M;Webster JP
通讯作者：
Webster JP
影响因子：
30.8
作者：
International Helminth Genomes Consortium
通讯作者：
International Helminth Genomes Consortium