Impediments to eye transplantation: ocular viability following optic-nerve transection or enucleation.
Impediments to eye transplantation: ocular viability following optic-nerve transection or enucleation.
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DOI：
10.1136/bjo.2008.155267
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发表时间：
2009-09
期刊：
影响因子：
--
通讯作者：
Azar DT
中科院分区：
文献类型：
--
作者：
Ellenberg D;Shi J;Jain S;Chang JH;Ripps H;Brady S;Melhem ER;Lakkis F;Adamis A;Chen DF;Ellis-Behnke R;Langer RS;Strittmatter SM;Azar DT
维持眼的存活能力是全眼移植成功的主要障碍之一。这篇综述提供了一个全面的了解目前的文献，以帮助指导未来的研究，以克服这一障碍。对已发表的文献进行了系统的多阶段综述。三个具体的问题得到解决：（1）与哺乳动物相比，冷血脊椎动物眼移植后的视觉功能恢复是否更大？(2)与单纯眼球摘除术相比，眼球摘除术和再灌注后视网膜外层功能是否得到改善？(3)视神经切断后，视网膜神经节细胞（RGC）存活率与切断后时间或切断部位与地球仪的接近程度是否存在相关性？在文献中进行的大多数研究中，在冷血脊椎动物的全眼移植后可发生视觉功能的恢复。眼球摘除（和再灌注）后，外部视网膜功能维持4至9小时。视神经切断后RGC的存活率与切断后的时间和离地球仪的距离成反比。最后，神经营养因子可以增加视神经切断后RGC的存活率。这篇文献回顾表明，使用供体眼进行全眼移植是可行的。
Maintenance of ocular viability is one of the major impediments to successful whole-eye transplantation. This review provides a comprehensive understanding of the current literature to help guide future studies in order to overcome this hurdle. A systematic multistage review of published literature was performed. Three specific questions were addressed: (1) Is recovery of visual function following eye transplantation greater in cold-blooded vertebrates when compared with mammals? (2) Is outer retina function following enucleation and reperfusion improved compared with enucleation alone? (3) Following optic-nerve transection, is there a correlation between retinal ganglion cell (RGC) survival and either time after transection or proximity of the transection to the globe? In a majority of the studies performed in the literature, recovery of visual function can occur after whole-eye transplantation in cold-blooded vertebrates. Following enucleation (and reperfusion), outer retinal function is maintained from 4 to 9 h. RGC survival following optic-nerve transection is inversely related to both the time since transection and the proximity of transection to the globe. Lastly, neurotrophins can increase RGC survival following optic-nerve transection. This review of the literature suggests that the use of a donor eye is feasible for whole-eye transplantation.
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影响因子：
1.8
作者：
BEAZLEY, LD;DARBY, JE;PERRY, VH
通讯作者：
PERRY, VH
影响因子：
3.4
作者：
Germain, F;Calvo, M;de la Villa, P
通讯作者：
de la Villa, P
影响因子：
5.3
作者：
GRAFSTEIN, B;INGOGLIA, NA
通讯作者：
INGOGLIA, NA
影响因子：
3.4
作者：
HUXLIN, KR;DREHER, B;BENNETT, MR
通讯作者：
BENNETT, MR
DOI：
10.1073/pnas.95.7.3978
发表时间：
1998-03-31
影响因子：
11.1
作者：
Di Polo, A;Aigner, LJ;Aguayo, AJ
通讯作者：
Aguayo, AJ