Threshold for Relationship between Vitamin D and Parathyroid Hormone in Chinese Women of Childbearing Age.
Threshold for Relationship between Vitamin D and Parathyroid Hormone in Chinese Women of Childbearing Age.
复制标题
中国育龄妇女维生素D与甲状旁腺激素关系的阈值
DOI：
10.3390/ijerph182413060
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发表时间：
2021-12-10
影响因子：
--
通讯作者：
Yang L
中科院分区：
文献类型：
--
作者：
Hu Y;Li S;Wang J;Zheng D;Zhang H;Yu W;Zhu L;Liu Z;Yang X;Yang L
背景：本研究的目的是评估中国育龄妇女血清 25-羟基维生素 D [25(OH)D] 与血清完整甲状旁腺激素 (PTH) 之间的关系，并估计最大程度抑制 PTH 的 25(OH)D 最佳阈值，这被认为是维生素 D 充足的最佳状态。方法：血清样本选自2015年中国慢性病与营养调查（CCDNS）生物样本库，采用液相色谱串联质谱法测定血清25（OH）D浓度，采用电子化学发光法测定血清PTH。利用简单线性和偏相关分析、局部加权回归平滑散点图（LOESS）、非线性最小二乘估计（NLS）和分段回归（SR）来估计25（OH）D和PTH的关系，并确定25（OH）D的阈值。结果：共分析了1568份血清样本的25(OH)D浓度和PTH浓度。在15.25（14.22-16.28）ng/mL以下观察到25（OH）D与PTH浓度之间存在显着的负相关关系，在按年龄、纬度、城市类型、季节、校正的钙和磷进行调整后，在16.75（15.43-18.06）ng/mL以上时，PTH随着25（OH）D的增加而缓慢下降。根据 LOESS、NLS 和 SR，以 25(OH)D 计，PTH 存在一个非常短的平台，分别为 15.25 ng/mL 和 16.75 ng/mL。结论：血清25(OH)D与血清PTH呈负相关。中国18-44岁育龄妇女血清25(OH)D浓度的维生素D充足阈值范围为14.22-18.06 ng/mL。
Background: The aim of this study was to assess the relationship between serum 25-hydroxyvitamin D [25(OH)D] and serum intact parathyroid hormone (PTH) in Chinese childbearing women, and to estimate the optimum threshold of 25(OH)D that maximally inhibits the PTH, which is considered to be the optimal status for vitamin D sufficiency. Methods: Serum samples were selected from the biological samples’ bank of the Chinese Chronic Diseases and Nutrition Survey (CCDNS) 2015. The serum 25(OH)D concentration was determined by liquid chromatography tandem mass spectrometry and the serum PTH was determined by electronic chemiluminescence. Simple linear and partial correlation analysis, locally weighted regression smooth scatterplot (LOESS), nonlinear least squares estimation (NLS), and segmented regression (SR) were utilized to estimate the relationship of 25(OH)D and PTH, and to determine the threshold of 25(OH)D. Results: A total of 1568 serum samples of 25(OH)D concentration and PTH concentration were analyzed. A significant inverse relationship between 25(OH)D and PTH concentration was observed below 15.25 (14.22–16.28) ng/mL, and PTH decreased slowly with the increase of 25(OH)D above 16.75 (15.43–18.06) ng/mL after adjusting by age, latitude, city type, season, corrected calcium, and phosphorus. A very short plateau of PTH was found at 15.25 ng/mL and 16.75 ng/mL in terms of 25(OH)D according to LOESS, NLS, and SR. Conclusions: The serum 25(OH)D was negatively correlated with the serum PTH. The threshold of VitD sufficiency was found in the range of 14.22–18.06 ng/mL in terms of serum 25(OH)D concentration for Chinese childbearing women aged 18–44 years old.
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影响因子：
4
作者：
Gutierrez, O. M.;Farwell, W. R.;Kermah, D.;Taylor, E. N.
通讯作者：
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影响因子：
3.7
作者：
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DOI：
10.1016/j.berh.2009.09.005
发表时间：
2009-12-01
影响因子：
5.2
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影响因子：
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影响因子：
3.7
作者：
Li M;Li Y;Deng W;Zhang Z;Deng Z;Hu Y;Xia W;Xu L
通讯作者：
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