Coupled oscillators coordinate collective germline growth.
Coupled oscillators coordinate collective germline growth.
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DOI：
10.1016/j.devcel.2021.02.015
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发表时间：
2021-03-22
影响因子：
11.8
通讯作者：
Shvartsman SY
中科院分区：
文献类型：
--
作者：
Doherty CA;Diegmiller R;Kapasiawala M;Gavis ER;Shvartsman SY
卵母细胞的发育需要大量的大分子和细胞器。积累这些产物的保守策略是汇集卵母细胞相关的生殖细胞资源。在果蝇中，这些细胞生长超过100倍，以提高其生物合成能力。以前没有已知的机制解释如何护士细胞协调生长集体。在这里，我们报告了一个细胞周期调节机制，依赖于卵母细胞和护士细胞之间的双向通信，揭示了卵母细胞作为生殖细胞囊肿生长的关键调节器。转录本编码的细胞周期蛋白依赖性激酶抑制剂，Dacapo，合成的护士细胞和积极定位到卵母细胞。卵母细胞合成的Dacapo蛋白向养育细胞的逆行运动产生耦合振荡器网络，其控制养育细胞的细胞周期以调节囊肿生长。我们提出，双向护士细胞卵母细胞通信建立了一个生长感应反馈机制，调节装载到卵母细胞的母体资源的数量。Doherty等人揭示了一种机制，即卵母细胞介导的细胞周期调节控制果蝇卵巢囊肿内支持护士细胞的集体生长。这种机制符合耦合振荡器进行同步的框架，并对生物学中其他类似的动力系统具有广泛的影响。
Developing oocytes need large supplies of macromolecules and organelles. A conserved strategy for accumulating these products is to pool resources of oocyte-associated germline nurse cells. In Drosophila, these cells grow more than 100-fold to boost their biosynthetic capacity. No previously known mechanism explains how nurse cells coordinate growth collectively. Here, we report a cell cycle-regulating mechanism that depends on bidirectional communication between the oocyte and nurse cells, revealing the oocyte as a critical regulator of germline cyst growth. Transcripts encoding the cyclin-dependent kinase inhibitor, Dacapo, are synthesized by the nurse cells and actively localized to the oocyte. Retrograde movement of the oocyte-synthesized Dacapo protein to the nurse cells generates a network of coupled oscillators that controls the cell cycle of the nurse cells to regulate cyst growth. We propose that bidirectional nurse cell-oocyte communication establishes a growth-sensing feedback mechanism that regulates the quantity of maternal resources loaded into the oocyte. Doherty et al. uncover a mechanism whereby oocyte-mediated cell cycle regulation controls the collective growth of supporting nurse cells within the Drosophila ovarian cyst. This mechanism fits the framework of coupled oscillators that undergo synchronization and has widespread implications for other similar dynamical systems in biology.
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影响因子：
64.8
作者：
Harris CR;Millman KJ;van der Walt SJ;Gommers R;Virtanen P;Cournapeau D;Wieser E;Taylor J;Berg S;Smith NJ;Kern R;Picus M;Hoyer S;van Kerkwijk MH;Brett M;Haldane A;Del Río JF;Wiebe M;Peterson P;Gérard-Marchant P;Sheppard K;Reddy T;Weckesser W;Abbasi H;Gohlke C;Oliphant TE
通讯作者：
Oliphant TE
DOI：
10.1002/wdev.294
发表时间：
2018-01
期刊：
Wiley interdisciplinary reviews. Developmental biology
影响因子：
--
作者：
Clarke HJ
通讯作者：
Clarke HJ
影响因子：
2.6
作者：
de Nooij, JC;Graber, KH;Hariharan, IK
通讯作者：
Hariharan, IK
影响因子：
64.5
作者：
Ferrell, James E., Jr.;Tsai, Tony Yu-Chen;Yang, Qiong
通讯作者：
Yang, Qiong
影响因子：
56.9
作者：
Lei, Lei;Spradling, Allan C.
通讯作者：
Spradling, Allan C.