Host defense peptides in the oral cavity and the lung: similarities and differences.
Host defense peptides in the oral cavity and the lung: similarities and differences.
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DOI：
10.1177/154405910808701011
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发表时间：
2008-10
影响因子：
7.6
通讯作者：
Ryan LK
中科院分区：
文献类型：
--
作者：
Diamond G;Beckloff N;Ryan LK
具有广谱抗微生物活性的肽存在于身体许多部位的粘膜表面，包括气道、口腔和消化道。基于它们的体外抗微生物和其他免疫调节活性，这些宿主防御肽已被提出在针对病原微生物定殖的先天防御中发挥重要作用。编码这些肽的基因被病原体上调，进一步支持它们在先天免疫防御中的作用。然而，一般无菌的气道和高度定植的口腔之间的局部微生物环境的差异表明这些肽在先天免疫中的作用更复杂。例如，所有细菌和Toll样受体（TLR）激动剂主要通过NF-κ B介导的途径在气道中诱导β-防御素基因。相反，相同的基因在牙龈上皮中仅由细菌和TLR配体的子集通过不同的途径诱导。此外，分泌肽的环境-特别是唾液、龈沟液和气道表面液-差异很大，并且可以影响它们各自在宿主防御中的活性。本文就口腔和气道中宿主防御肽的异同作一综述，以更好地了解它们对免疫的贡献。
Peptides with broad-spectrum antimicrobial activity are found in the mucosal surfaces at many sites in the body, including the airway, the oral cavity, and the digestive tract. Based on their in vitro antimicrobial and other immunomodulatory activities, these host defense peptides have been proposed to play an important role in the innate defense against pathogenic microbial colonization. The genes that encode these peptides are up-regulated by pathogens, further supporting their role in innate immune defense. However, the differences in the local microbial environments between the generally sterile airway and the highly colonized oral cavity suggest a more complex role for these peptides in innate immunity. For example, β-defensin genes are induced in the airway by all bacteria and Toll-like receptor (TLR) agonists primarily through an NF-κB-mediated pathway. In contrast, the same genes are induced in the gingival epithelium by only a subset of bacteria and TLR ligands, via different pathways. Furthermore, the environments into which the peptides are secreted—specifically saliva, gingival crevicular fluid, and airway surface fluid—differ greatly and can effect their respective activities in host defense. In this review, we examine the differences and similarities between host defense peptides in the oral cavity and the airway, to gain a better understanding of their contributions to immunity.
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影响因子：
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DOI：
10.1165/ajrcmb.25.1.4436
发表时间：
2001-07-01
影响因子：
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作者：
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