Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin.
Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin.
复制标题
作者：
蜜蜂和人类等不同物种的社会行为促进群体生存，但往往会给个人带来一些损失。尽管表面上这些行为的进化持久性需要加强适应性社交互动，但大脑编码社交奖励的神经机制在很大程度上是未知的。在这里，我们证明，在小鼠中，催产素（OT）在伏隔核（NAc）核心内充当社会强化信号，在中型多刺神经元中引起突触前表达的兴奋性突触传递的长期抑制。尽管 NAc 从多个大脑区域接收包含 OT 受体的输入，但这些受体（特别是中缝背核）的基因删除（为 NAc 提供血清素能 (5-HT) 神经支配）消除了社交互动的强化特性。此外，OT 诱导的突触可塑性需要 NAc 5-HT1b 受体的激活，该受体的阻断会阻碍社会奖励。这些结果表明，小鼠社交互动的有益特性需要 NAc 中 OT 和 5-HT 的协调活动，这是一种机制见解，有助于理解自闭症等神经精神疾病中社交功能障碍的发病机制。
Social behaviors in species as diverse as honey bees and humans promote group survival but often come at some cost to the individual. Although reinforcement of adaptive social interactions is ostensibly required for the evolutionary persistence of these behaviors, the neural mechanisms by which social reward is encoded by the brain are largely unknown. Here we demonstrate that in mice oxytocin (OT) acts as a social reinforcement signal within the nucleus accumbens (NAc) core, where it elicits a presynaptically expressed long-term depression of excitatory synaptic transmission in medium spiny neurons. Although the NAc receives OT receptor-containing inputs from several brain regions, genetic deletion of these receptors specifically from dorsal raphe nucleus, which provides serotonergic (5-HT) innervation to the NAc, abolishes the reinforcing properties of social interaction. Furthermore, OT-induced synaptic plasticity requires activation of NAc 5-HT1b receptors, the blockade of which prevents social reward. These results demonstrate that the rewarding properties of social interaction in mice require the coordinated activity of OT and 5-HT in the NAc, a mechanistic insight with implications for understanding the pathogenesis of social dysfunction in neuropsychiatric disorders such as autism.
登录
查看更多内容
影响因子：
1.6
作者：
Hodgson SR;Hofford RS;Roberts KW;Wellman PJ;Eitan S
通讯作者：
Eitan S
影响因子：
64.8
作者：
Cui, Guohong;Jun, Sang Beom;Jin, Xin;Pham, Michael D.;Vogel, Steven S.;Lovinger, David M.;Costa, Rui M.
通讯作者：
Costa, Rui M.
影响因子：
56.9
作者：
Aronov, Dmitriy;Andalman, Aaron S.;Fee, Michale S.
通讯作者：
Fee, Michale S.
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
5.4
作者：
Grimm, Dirk;Lee, Joyce S.;Kay, Mark A.
通讯作者：
Kay, Mark A.