Circadian oscillation of hippocampal MAPK activity and cAmp: implications for memory persistence.
Circadian oscillation of hippocampal MAPK activity and cAmp: implications for memory persistence.
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DOI：
10.1038/nn.2174
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发表时间：
2008-09
影响因子：
25
通讯作者：
Storm, Daniel R.
中科院分区：
文献类型：
--
作者：
Eckel-Mahan, Kristin L.;Phan, Trongha;Han, Sung;Wang, Hongbing;Chan, Guy C-K;Scheiner, Zachary S.;Storm, Daniel R.
有丝分裂原活化蛋白激酶（MAPK）和环磷酸腺苷（cAMP）信号传导途径在海马依赖性记忆的巩固中发挥关键作用。我们发现，细胞外调节激酶1/2 MAPK磷酸化和cAMP在海马中经历了一个昼夜节律振荡，这是由Ras活性和MAPK激酶和cAMP反应元件结合蛋白（CREB）的磷酸化的变化所引起的。这个激活周期的最低点对应于严重的赤字，在光暗和自由运行的条件下，依赖于校园的恐惧条件反射。cAMP和MAPK活性的昼夜节律振荡在缺乏钙离子刺激的腺苷酸环化酶的记忆缺陷转基因小鼠中不存在。此外，在细胞记忆巩固期后，生理和药理学干扰MAPK磷酸化的振荡损害了海马依赖性记忆的持久性。这些数据表明，长期记忆的持久性可能取决于在昼夜节律周期中海马中cAMP/MAPK/CREB转录途径的重新激活。
The mitogen-activated protein kinase (MAPK) and cyclic adenosine monophosphate (cAMP) signal transduction pathways have critical roles in the consolidation of hippocampus-dependent memory. We found that extracellular regulated kinase 1/2 MAPK phosphorylation and cAMP underwent a circadian oscillation in the hippocampus that was paralleled by changes in Ras activity and the phosphorylation of MAPK kinase and cAMP response element-binding protein (CREB). The nadir of this activation cycle corresponded with severe deficits in hippocampus-dependent fear conditioning under both light-dark and free-running conditions. Circadian oscillations in cAMP and MAPK activity were absent in memory-deficient transgenic mice that lacked Ca2+-stimulated adenylyl cyclases. Furthermore, physiological and pharmacological interference with oscillations in MAPK phosphorylation after the cellular memory consolidation period impaired the persistence of hippocampus-dependent memory. These data suggest that the persistence of long-term memories may depend on reactivation of the cAMP/MAPK/CREB transcriptional pathway in the hippocampus during the circadian cycle.
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影响因子：
25
作者：
Athos, J;Impey, S;Storm, DR
通讯作者：
Storm, DR
DOI：
10.1016/s0091-6773(73)80164-6
发表时间：
1973-01-01
期刊：
BEHAVIORAL BIOLOGY
影响因子：
--
作者：
HOLLOWAY, FA;WANSLEY, RA
通讯作者：
WANSLEY, RA
DOI：
10.1073/pnas.92.19.8851
发表时间：
1995-09-12
影响因子：
11.1
作者：
BRANDON, EP;ZHUO, M;IDZERDA, RL
通讯作者：
IDZERDA, RL
影响因子：
2.7
作者：
Devan, BD;Goad, EH;McDonald, RJ
通讯作者：
McDonald, RJ
影响因子：
64.5
作者：
Huang, YY;Kandel, ER;Bourtchouladze, R
通讯作者：
Bourtchouladze, R