Bacteriophages: Protagonists of a Post-Antibiotic Era.

Bacteriophages: Protagonists of a Post-Antibiotic Era.
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DOI:
10.3390/antibiotics7030066
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发表时间:
2018-07-27
期刊:
Antibiotics (Basel, Switzerland)
影响因子:
--
通讯作者:
Delgado-Martínez J
Delgado-Martínez J
中科院分区:
其他
文献类型:
--
作者:
Domingo-Calap P;Delgado-Martínez J

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尽管抗生素在半个多世纪以来取得了长期的成功,但由于多重耐药细菌的出现,抗生素目前正处于聚光灯下。新的替代治疗方法的开发在对抗细菌耐药性方面特别令人感兴趣。噬菌体(Bacteriophages,简称BPHs)是细菌的天然杀手,由于其特异性和生态安全性,是一种很好的工具。在这里,我们强调了它们作为潜在治疗剂的一些优点和缺点。有趣的是,抗生素不仅从临床角度来看具有吸引力,而且其他领域,如农业,食品控制或工业,也是其潜在应用的领域。因此,我们建议将其作为当前抗生素的真实的替代品。
Despite their long success for more than half a century, antibiotics are currently under the spotlight due to the emergence of multidrug-resistant bacteria. The development of new alternative treatments is of particular interest in the fight against bacterial resistance. Bacteriophages (phages) are natural killers of bacteria and are an excellent tool due to their specificity and ecological safety. Here, we highlight some of their advantages and drawbacks as potential therapeutic agents. Interestingly, phages are not only attractive from a clinical point of view, but other areas, such as agriculture, food control, or industry, are also areas for their potential application. Therefore, we propose phages as a real alternative to current antibiotics.
DOI: 10.1084/jem.133.5.1105
发表时间: 1971-05-01
期刊: The Journal of experimental medicine
影响因子: --
作者:
Fischetti VA;Gotschlich EC;Bernheimer AW
通讯作者: Bernheimer AW
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