IKKα is involved in kidney recovery and regeneration of acute ischemia/reperfusion injury in mice through IL10-producing regulatory T cells.
IKKα is involved in kidney recovery and regeneration of acute ischemia/reperfusion injury in mice through IL10-producing regulatory T cells.
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DOI：
10.1242/dmm.018200
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发表时间：
2015-07-01
影响因子：
4.3
通讯作者：
Cao CC
中科院分区：
文献类型：
--
作者：
Wan X;Hou LJ;Zhang LY;Huang WJ;Liu L;Zhang Q;Hu B;Chen W;Chen X;Cao CC
肾脏缺血/再灌注（IR）损伤后的恢复阶段通常与炎症的抑制和肾小管上皮细胞（TEC）的增殖有关。该阶段的持续时间通常取决于炎症的抑制和 TEC 的增殖。多项证据表明，IκB 激酶 α (IKKα) 不仅可以促进抗炎因子的产生和/或阻止炎症因子的产生，还可以诱导伴随的细胞分化和再生，并抑制炎症。因此，我们假设 IKKα 可以参与 IR 损伤后的肾脏修复，并使用急性肾损伤 (AKI) 小鼠模型来测试这一点。我们发现 IKKα 通过浸润的调节性 T (Treg) 细胞介导肾脏修复，该细胞可以产生抗炎细胞因子 IL10，并且 IKKα 还可以增加存活 TEC 的增殖并抑制炎症。此外，TECs中吲哚胺2,3-双加氧酶（IDO）的表达与产生IL10的Treg细胞的浸润一致。我们得出的结论是，IKKα 通过可产生 IL10 的 Treg 细胞参与肾脏恢复和再生，这可能是可用于促进 IR 损伤后肾脏修复的潜在治疗靶点。摘要：IKKα 通过分泌 IL10 的调节性 T 细胞参与肾脏恢复和再生。
The recovery phase after kidney ischemia/reperfusion (IR) injury is often associated with the suppression of inflammation and the proliferation of tubular epithelial cells (TECs). The duration of this phase is often determined by the suppression of inflammation and the proliferation of TECs. Several lines of evidence suggest that IκB kinase α (IKKα) not only promotes the production of anti-inflammatory factors and/or prevents the production of inflammatory factors, but also induces the accompanying cell differentiation and regeneration, and suppresses inflammation. We therefore hypothesized that IKKα could participate in the kidney repair after IR injury and have used a mouse model of acute kidney injury (AKI) to test this. We found that IKKα mediated the repair of the kidney via infiltrated regulatory T (Treg) cells, which can produce anti-inflammatory cytokine IL10, and that IKKα also increased the proliferation of the surviving TECs and suppressed of inflammation. In addition, the expression of indoleamine 2,3-dioxygenase (IDO) in TECs is consistent with the infiltration of IL10-producing Treg cells. We conclude that IKKα is involved in kidney recovery and regeneration through the Treg cells that can produce IL10, which might be a potential therapeutic target that can be used to promote kidney repair after IR injury. Summary: IKKα in the kidney recovery and regeneration via regulatory T cells secreting IL10.
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DOI：
10.1111/j.1600-6143.2012.04203.x
发表时间：
2012-11
期刊：
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子：
--
作者：
Chen G;Kheradmand T;Bryant J;Wang S;Tasch J;Wang JJ;Zhang Z;Luo X
通讯作者：
Luo X
影响因子：
11.4
作者：
Descargues, Pascal;Sil, Alok K.;Karin, Michael
通讯作者：
Karin, Michael
影响因子：
9.1
作者：
Costantino, Cristina Maria;Baecher-Allan, Clare;Hafler, David A.
通讯作者：
Hafler, David A.
影响因子：
168.9
作者：
Benigni, Ariela;Morigi, Marina;Remuzzi, Giuseppe
通讯作者：
Remuzzi, Giuseppe
影响因子：
64.8
作者：
Lawrence, T;Bebien, M;Karin, M
通讯作者：
Karin, M