Relation between cord blood mercury levels and early child development in a World Trade Center cohort.
Relation between cord blood mercury levels and early child development in a World Trade Center cohort.
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DOI：
10.1289/ehp.10831
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发表时间：
2008-08
影响因子：
10.4
通讯作者：
Perera, Frederica A.
中科院分区：
文献类型：
--
作者：
Lederman, Sally Ann;Jones, Robert L.;Caldwell, Kathleen L.;Rauh, Virginia;Sheets, Stephen E.;Tang, Deliang;Viswanathan, Sheila;Becker, Mark;Stein, Janet L.;Wang, Richard Y.;Perera, Frederica A.
这项研究旨在确定产前汞暴露，包括世界贸易中心（WTC）灾难的潜在释放，是否会对胎儿生长和儿童发育产生不利影响。我们测定了2001年9月11日后在下曼哈顿足月分娩的非吸烟妇女的母体和脐带血总汞，并测量了分娩结局和儿童发育。在9月11日之后的一个月里，居住或工作在世贸中心1或2英里范围内的妇女，脐带血和母体血中的总汞水平并没有明显高于居住和工作在更远地方的妇女。平均脐带汞水平是母体水平的两倍多，并且在怀孕期间报告吃鱼/海鲜的妇女中两者都升高。回归分析显示脐带血或母血总汞与出生结局之间无显著相关性。对数脐带汞与36个月时的贝利婴儿发育量表精神发育评分[精神发育指数（PDI）]呈负相关（B =-4.2，p = 0.007）和性能（B =-3.4，p = 0.023），口头（B =-2.9，p = 0.023）和全智商评分（B =-3.8，p = 0.002），在48个月时，在控制鱼类/海鲜消费和其他混杂因素后。怀孕期间食用鱼类/海鲜与36个月的PDI和48个月的言语和全面智商得分增加5.6至9.9分显著相关。在2001年9月11日之后的几周内，在世贸中心附近生活或工作的妇女的血汞没有显著升高。在调整了怀孕期间食用鱼/海鲜的积极影响后，较高的脐带血汞与36和48个月时发育评分的降低有关。
This study was designed to determine whether prenatal mercury exposure, including potential releases from the World Trade Center (WTC) disaster, adversely affects fetal growth and child development. We determined maternal and umbilical cord blood total mercury of nonsmoking women who delivered at term in lower Manhattan after 11 September 2001, and measured birth outcomes and child development. Levels of total mercury in cord and maternal blood were not significantly higher for women who resided or worked within 1 or 2 miles of the WTC in the month after 11 September, compared with women who lived and worked farther away. Average cord mercury levels were more than twice maternal levels, and both were elevated in women who reported eating fish/seafood during pregnancy. Regression analyses showed no significant association between (ln) cord or maternal blood total mercury and birth outcomes. Log cord mercury was inversely associated with the Bayley Scales of Infant Development psychomotor score [Psychomotor Development Index (PDI)] at 36 months (b = –4.2, p = 0.007) and with Performance (b = –3.4, p = 0.023), Verbal (b = –2.9, p = 0.023), and Full IQ scores (b = –3.8, p = 0.002) on the Wechsler Preschool and Primary Scale of Intelligence, Revised (WPPSI-R), at 48 months, after controlling for fish/seafood consumption and other confounders. Fish/seafood consumption during pregnancy was significantly associated with a 5.6- to 9.9-point increase in 36-month PDI, and 48-month Verbal and Full IQ scores. Blood mercury was not significantly raised in women living or working close to the WTC site in the weeks after 11 September 2001. Higher cord blood mercury was associated with reductions in developmental scores at 36 and 48 months, after adjusting for the positive effects of fish/seafood consumption during pregnancy.
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影响因子：
10.4
作者：
McGee JK;Chen LC;Cohen MD;Chee GR;Prophete CM;Haykal-Coates N;Wasson SJ;Conner TL;Costa DL;Gavett SH
通讯作者：
Gavett SH
影响因子：
10.4
作者：
Lioy PJ;Weisel CP;Millette JR;Eisenreich S;Vallero D;Offenberg J;Buckley B;Turpin B;Zhong M;Cohen MD;Prophete C;Yang I;Stiles R;Chee G;Johnson W;Porcja R;Alimokhtari S;Hale RC;Weschler C;Chen LC
通讯作者：
Chen LC
影响因子：
7.5
作者：
Gill, B;Chang, J;Palmer, S
通讯作者：
Palmer, S
影响因子：
10.4
作者：
Grandjean P;Budtz-Jørgensen E;Jørgensen PJ;Weihe P
通讯作者：
Weihe P
DOI：
10.1016/s0584-8547(99)00057-9
发表时间：
1999-08-09
影响因子：
3.3
作者：
Nixon, DE;Burritt, MF;Moyer, TP
通讯作者：
Moyer, TP